{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:40:43Z","timestamp":1772779243094,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-limited settings. We evaluated the diagnostic usefulness of Xpert MTB\/RIF compared with TB culture among SNPTB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was a cross-sectional study among patients with SNPTB. The Xpert MTB\/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB\/RIF were 81.8 and 97.4%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The sensitivity and specificity of Xpert MTB\/RIF assay was comparative with culture in SNPTB patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa019","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:14:07Z","timestamp":1584620047000},"page":"697-699","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of GeneXpert MTB\/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria"],"prefix":"10.1093","volume":"114","author":[{"given":"Abdulwasiu Bolaji","family":"Tiamiyu","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garba","family":"Iliyasu","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, College of Health Sciences, Bayero University Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farouq Muhammad","family":"Dayyab","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaiyad Garba","family":"Habib","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirajo Haliru","family":"Tambuwal","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibu","family":"Galadanci","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Hospital, Abuja, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunday A","family":"Bwala","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Hospital, Abuja, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovett","family":"Lawson","sequence":"additional","affiliation":[{"name":"Zankli Medical Centre, Abuja, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrazaq Garba","family":"Habib","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medicine, College of Health Sciences, Bayero University Kano, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"2020083020421299700_ref1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1473-3099(11)70057-3","article-title":"Use of a WHO-recommended algorithm to reduce mortality in seriously ill patients with HIV infection and smear-negative pulmonary tuberculosis in South Africa: An observational cohort study","volume":"11","author":"Holtz","year":"2011","journal-title":"The Lancet Infect Dis."},{"key":"2020083020421299700_ref2","author":"World Health Organization"},{"key":"2020083020421299700_ref3","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/cid\/cis631","article-title":"Evaluation of the Xpert MTB\/RIF assay at a tertiary care referral hospital in a setting where tuberculosis and HIV infection are highly endemic","volume":"55","author":"O'Grady","year":"2012","journal-title":"CID."},{"key":"2020083020421299700_ref4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jinf.2012.02.012","article-title":"Rapid and effective diagnosis of tuberculosis and rifampicin resistance with Xpert MTB\/RIF assay: A meta-analysis","volume":"64","author":"Chang","year":"2012","journal-title":"J Infect."},{"key":"2020083020421299700_ref5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(11)60438-8","article-title":"Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB\/RIF test for diagnosis of tuberculosis and multidrug resistance: A multicentre implementation study","volume":"377","author":"Boehme","year":"2011","journal-title":"Lancet."}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/114\/9\/697\/33698769\/traa019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/114\/9\/697\/33698769\/traa019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T17:31:32Z","timestamp":1598895092000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/114\/9\/697\/5821068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":5,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,4,17]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/traa019","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,4,17]]}}}