{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:20:06Z","timestamp":1783466406168,"version":"3.55.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Nawaloka Hospital, Colombo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of steroids in dengue infection (DI) remains uncertain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective chart review was conducted on patients \u226518\u00a0y of age diagnosed with DI based on positivity for dengue non-structural antigen 1 or immunoglobulin M between October 2017 and November 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Hydrocortisone was administered to 106 of 406 patients. DI with warning signs occurred in nine patients (9.5%) in the steroid cohort and eight patients (2.5%) in the non-steroid group. The incidence of severe DI, bleeding and admission duration were similar between the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study shows no significant benefit of empirical steroids in DI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa049","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T11:11:49Z","timestamp":1591269109000},"page":"632-634","source":"Crossref","is-referenced-by-count":3,"title":["The impact of empirical hydrocortisone therapy on clinical outcomes in dengue fever: a retrospective chart review"],"prefix":"10.1093","volume":"114","author":[{"given":"Sanjay","family":"de Mel","sequence":"first","affiliation":[{"name":"Department of Haematology\u2013Oncology, National University Cancer Institute, National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basuru Uvindu","family":"Thilakawardana","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primesh","family":"de Mel","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjuna P","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Ragama, University of Kelaniya, Kelaniya, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandima","family":"de Mel","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lal","family":"Chandrasena","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suranjith L","family":"Seneviratne","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri Lanka"},{"name":"Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka"},{"name":"Institute of Immunity and Transplantation, Royal Free Hospital and University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visula","family":"Abeysuriya","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo, Sri 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