{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:27:14Z","timestamp":1785374834657,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Foundation for Research Support of the State of Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Science and Technology in Theranostics and Nanobiotechnology","award":["CNPq 465669\/2014-0"],"award-info":[{"award-number":["CNPq 465669\/2014-0"]}]},{"name":"National Institute of Science and Technology in Theranostics and Nanobiotechnology","award":["FAPEMIG-CBB-APQ-03613-17"],"award-info":[{"award-number":["FAPEMIG-CBB-APQ-03613-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The early recognition of neural impairment in leprosy, especially in primary neural forms, represents a challenge in clinical practice and a peripheral nerve biopsy may be required for diagnostic confirmation. This study aims to characterize the epidemiological, clinical, electroneuromyographic, laboratory and histopathological aspects of patients undergoing peripheral nerve biopsy during investigation of primary neural cases in leprosy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 104 patients with peripheral neuropathy who were referred to a national reference centre for leprosy were biopsied from 2014 to 2018. All cases underwent clinical, laboratory, histopathological and electroneuromyographic evaluations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 104 biopsied patients, leprosy was confirmed in 89.4% (93\/104). The biopsied nerves were the ulnar (67.8% [63\/93]), superficial fibular (21.5% [20\/93]), sural (8.6% [8\/93]), radial (1.1% [1\/93]) and deep fibular (1.1% [1\/93]). Twenty-nine percent (27\/93) presented histopathological abnormalities and 4.4% (4\/93) presented acid-fast bacilli. Nerve and superjacent skin quantitative polymerase chain reaction were positive in 49.5% (46\/93) and 24.8% (23\/93) of cases, respectively. Patients with multiple mononeuropathy had a higher frequency of histopathological abnormalities (p=0.0077).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study reinforces peripheral nerve biopsy's role as an important tool in the investigation of primary neural cases, contributing to the early diagnosis and also reducing diagnostic errors and the need for empirical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa053","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:13:40Z","timestamp":1593717220000},"page":"792-797","source":"Crossref","is-referenced-by-count":12,"title":["Peripheral nerve biopsy: a tool still needed in the early diagnosis of neural leprosy?"],"prefix":"10.1093","volume":"114","author":[{"given":"Diogo Fernandes","family":"dos Santos","sequence":"first","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"},{"name":"Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Eul\u00e1lio","family":"Antunes","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"},{"name":"Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Carvalho","family":"Dornelas","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"},{"name":"Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Araujo","family":"da Cunha","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Junqueira","family":"Oliveira","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Campos","family":"Pereira","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Ricardo","family":"Goulart","sequence":"additional","affiliation":[{"name":"National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, Brazil"},{"name":"Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberl\u00e2ndia (UFU), 1720 Par\u00e1 Avenue, Uberl\u00e2ndia, MG, 38400-902, 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