{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:05:52Z","timestamp":1792757152672,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tuberculosis (TB) is an important public health problem in China and environmental and genetic factors have an impact on its occurrence and development. We explored the relationship between environmental factors, genetic susceptibility genes and gene\u2013environment interactions and the incidence of TB, as well as their high-risk combination, which can provide a scientific basis for prevention of the disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The 242 individuals, which included 82 TB patients, 67 family genetically related patients and 93 healthy controls, all of whom were of the Han population in Guangdong Province. The basic information of subjects was collected, including general conditions, behaviour habits, family environmental factors and blood samples. Two single nucleotides with potential functions (interleukin-10 [IL-10] rs1800896, interferon-\u03b3 [IFN-\u03b3] rs2430561) were screened by bioinformatics tools and identified by polymerase chain reaction\u2013restriction fragment length polymorphism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that gender, education, TB exposure history, fitness activities, residential areas and indoor hygiene conditions were all associated with the occurrence of TB. In the dominant model, AG+GG of IL-10 and AA of IFN-\u03b3 are high-risk genotypes. Multifactor dimensionality reduction (MDR) analysis of TB-prone families shows that a combination of male sex, IL-10 AA and AG genotypes and smoking history are elements of high risk for TB infection (prediction accuracy 62.45%, cross-validation consistency 10\/10). The MDR analysis of the TB patients group and the healthy control group showed that the combination of low education level, history of TB exposure, and IFN-\u03b3 AA genotype represented a higher risk of TB infection (prediction accuracy 80.34%, cross-validation consistency 10\/10).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The occurrence of TB in TB-prone families in the Han population of Guangdong Province is related to environmental factors as well as cytokines IL-10 and IFN-\u03b3. We also found high-risk combinations of genes and environmental factors, providing clues for the timely detection of high-risk groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa076","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:36:59Z","timestamp":1596541019000},"page":"20-29","source":"Crossref","is-referenced-by-count":5,"title":["Association of gene polymorphisms and environmental factors in tuberculosis patients and their household contacts"],"prefix":"10.1093","volume":"115","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Feng","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao Guo","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, 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