{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:12:20Z","timestamp":1792131140075,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009826","name":"University of Colombo, Sri Lanka","doi-asserted-by":"publisher","award":["AP\/3\/2\/2017\/CG\/25"],"award-info":[{"award-number":["AP\/3\/2\/2017\/CG\/25"]}],"id":[{"id":"10.13039\/501100009826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council, Australia","doi-asserted-by":"publisher","award":["1173666"],"award-info":[{"award-number":["1173666"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients compared with non-dengue fever patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post-infection fatigue and its demographic and clinical associations were assessed in adult dengue and non-dengue fever patients 2\u00a0months after the acute infection in a prospective cohort study in Sri Lanka. Fatigue at 2\u00a0months (primary endpoint) was assessed with the fatigue questionnaire as a dichotomous outcome based on a pre-recommended cut-off (score \u22654) and as the total score from the questionnaire (higher score indicates more fatigue).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 260 patients, 158 had dengue and, of these, 51 (32%) had fatigue at 2\u00a0months. Risk was higher in dengue patients (vs non-dengue; relative risk [RR] 4.93 [95% confidence interval {CI} 2.3 to 10.4]) and more so in female dengue patients (vs male dengue patients; RR 2.45 [95% CI 1.24 to 4.86]). Severe dengue patients had a higher mean fatigue score (p=0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post-infection fatigue is an underappreciated burden of this widely prevalent infection. Our findings are useful to triage patients at risk of fatigue for follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/traa110","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T11:59:25Z","timestamp":1601380765000},"page":"669-676","source":"Crossref","is-referenced-by-count":31,"title":["Dengue and post-infection fatigue: findings from a prospective cohort\u2014the Colombo Dengue Study"],"prefix":"10.1093","volume":"115","author":[{"given":"Ponsuge C","family":"Sigera","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Colombo, 00800, Colombo 08, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senaka","family":"Rajapakse","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 00800, Colombo 08, Sri 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