{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:06:20Z","timestamp":1784862380152,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIHR Global Health Research Unit on NTDs"},{"name":"Brighton and Sussex Medical School","award":["16\/136\/29"],"award-info":[{"award-number":["16\/136\/29"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["201900\/Z\/16\/Z"],"award-info":[{"award-number":["201900\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Podoconiosis, lymphatic filariasis (LF) and leprosy are neglected tropical diseases (NTDs) that cause lymphoedema. When left untreated, they lead to substantial disability. This study determined the quality of life (QOL) and depression associated with lymphoedema in patients with podoconiosis, LF and leprosy. The study was conducted in northwestern Ethiopia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This baseline cross-sectional study, nested within an interventional, non-comparative, longitudinal study, included patients with lymphoedema. Depression and QOL were assessed using versions of the 9-item Patient Health Questionnaire and Dermatologic Life Quality Index (DLQI), respectively, that had been translated into Amharic and validated. Factors associated with depression and QOL were assessed using multivariate linear regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 251 patients with lymphoedema included in the study, 119 (47.4%) had moderate to severe depression and overall QOL was poor (mean\u00b1standard deviation [SD] DLQI score: 11.4\u00b14.2). Disability was significantly associated with depression (\u03b2=0.26 [95% confidence interval {CI} 0.19 to 0.33]). Currently receiving treatment (\u03b2=\u22123.05 [95% CI \u22125.25 to \u22120.85), disability (\u03b2=\u22120.08 [95% CI \u22120.15 to \u22120.01]) and social support (moderate support: \u03b2=\u22122.27 [95% CI \u22123.66 to \u22120.89] and strong support: \u03b2=\u22122.87 [95% CI \u22125.35 to \u22120.38]) were significantly associated with better QOL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>High levels of depression and low QOL were found among patients with lymphoedema due the three NTDs in Ethiopia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa130","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T12:30:53Z","timestamp":1604925053000},"page":"983-994","source":"Crossref","is-referenced-by-count":31,"title":["A cross-sectional study to evaluate depression and quality of life among patients with lymphoedema due to podoconiosis, lymphatic filariasis and leprosy"],"prefix":"10.1093","volume":"114","author":[{"given":"Oumer","family":"Ali","sequence":"first","affiliation":[{"name":"Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT)-Africa, College of Health Sciences, Addis Ababa University, Addis Ababa, 9086, Ethiopia"},{"name":"Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1\u00a09PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-6996","authenticated-orcid":false,"given":"Kebede","family":"Deribe","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1\u00a09PX, UK"},{"name":"School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, 1176, 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