{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:28:20Z","timestamp":1789183700448,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding and describing the regional and climatic patterns associated with increasing dengue epidemics in Nepal is critical to improving vector and disease surveillance and targeting control efforts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the spatial and temporal patterns of annual dengue incidence in Nepal from 2010 to 2019, and the impacts of seasonal meteorological conditions (mean maximum, minimum temperature and precipitation) and elevation on those patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than 25 000 laboratory-confirmed dengue cases were reported from 2010 to 2019. Epidemiological trends suggest that dengue epidemics are cyclical with major outbreaks occurring at 2- to 3-y intervals. A significant negative relationship between dengue incidence and increasing elevation (metres above sea level) driven by temperature was observed (p&amp;lt;0.05) with dengue risk being greatest below 500 m. Risk was moderate between 500 and 1500 m and decreased substantially above 1500 m. Over the last decade, increased nightly temperatures during the monsoon months correlated with increased transmission (p&amp;lt;0.05). No other significant relationship was observed between annual dengue cases or incidence and climatological factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The spatial analysis and interpretation of dengue incidence over the last decade in Nepal confirms that dengue is now a well-established public health threat of increasing importance, particularly in low elevation zones and urbanised areas with a tropical or subtropical climate. Seasonal variations in temperature during the monsoon months are associated with increased transmission.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/traa131","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T12:11:29Z","timestamp":1604491889000},"page":"741-749","source":"Crossref","is-referenced-by-count":24,"title":["Patterns of dengue in Nepal from 2010\u20132019 in relation to elevation and climate"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-8315","authenticated-orcid":false,"given":"Narayan","family":"Gyawali","sequence":"first","affiliation":[{"name":"Mosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia"},{"name":"Biomedical Research Unit, Centre for Molecular Dynamics Nepal, Kathmandu 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Johnson","sequence":"additional","affiliation":[{"name":"Mosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer M","family":"Dixit","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit, Centre for Molecular Dynamics Nepal, Kathmandu 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor J","family":"Devine","sequence":"additional","affiliation":[{"name":"Mosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"2021063023535203900_bib1","first-page":"157","article-title":"First case of Dengue virus infection in Nepal","volume":"6","author":"Pandey","year":"2004","journal-title":"Nepal Med Coll J"},{"key":"2021063023535203900_bib2","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3201\/eid1410.080432","article-title":"Identification of all dengue serotypes in Nepal","volume":"14","author":"Malla","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"2021063023535203900_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2149\/tmh.2012-17","article-title":"First isolation of dengue virus from the 2010 epidemic in Nepal","volume":"41","author":"Pandey","year":"2013","journal-title":"Trop Med Health"},{"key":"2021063023535203900_bib4","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4269\/ajtmh.17-0221","article-title":"Dengue virus serotypes 1 and 2 responsible for major dengue outbreaks in Nepal: clinical, laboratory, and epidemiological features","volume":"97","author":"Dumre","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"2021063023535203900_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4103\/0971-5916.176564","article-title":"Re-emergence of dengue virus serotype 2 strains in the 2013 outbreak in Nepal","volume":"142","author":"Gupta","year":"2015","journal-title":"Indian J Med Res"},{"key":"2021063023535203900_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.meegid.2015.07.006","article-title":"Phylogenetic study reveals co-circulation of Asian II and Cosmopolitan genotypes of dengue virus serotype 2 in Nepal during 2013","volume":"34","author":"Singh","year":"2015","journal-title":"Infect Genet Evol"},{"key":"2021063023535203900_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12941-018-0258-9","article-title":"Dengue periodic outbreaks and epidemiological trends in Nepal","volume":"17","author":"Gupta","year":"2018","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2021063023535203900_bib8","volume-title":"Epidemiology of Disease Control Division Nepal","author":"EDCD, Nepal"},{"key":"2021063023535203900_bib9","author":"Health Mos","year":"2017"},{"key":"2021063023535203900_bib10","volume-title":"Central Bureau of Statistics, Nepal. 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