{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:49:54Z","timestamp":1770918594035,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/traa168","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T23:34:19Z","timestamp":1610667259000},"page":"324-327","source":"Crossref","is-referenced-by-count":8,"title":["Melanin production in coelomycetous agents of black grain eumycetoma"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-3825","authenticated-orcid":false,"given":"Wilson","family":"Lim","sequence":"first","affiliation":[{"name":"Erasmus MC , University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florianne","family":"Parel","sequence":"additional","affiliation":[{"name":"Erasmus MC , University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology of Radboud University Medical Center\/Canisius Wilhelmina Hospital, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Verbon","sequence":"additional","affiliation":[{"name":"Erasmus MC , University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy W J","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Erasmus MC , University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"issue":"11","key":"2021041419231978900_bib1","doi-asserted-by":"crossref","first-page":"e2550","DOI":"10.1371\/journal.pntd.0002550","article-title":"Global burden of human mycetoma: a systematic review and meta-analysis","volume":"7","author":"van de Sande","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"2021041419231978900_bib2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.micinf.2007.05.015","article-title":"Melanin biosynthesis in Madurella mycetomatis and its effect on susceptibility to itraconazole and ketoconazole","volume":"9","author":"van de Sande","year":"2007","journal-title":"Microbes Infect"},{"key":"2021041419231978900_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1179\/joc.2003.15.Supplement-2.36","article-title":"Epidemiology, clinical manifestations, and therapy 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