{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:44:19Z","timestamp":1772005459670,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["S0008-2015-1"],"award-info":[{"award-number":["S0008-2015-1"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["261153"],"award-info":[{"award-number":["261153"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients affected by neurocysticercosis (NCC), the extraparenchymal location of the parasites generates the most severe form of the disease. Due to the difficulty in its diagnosis and management, there are still many questions; in particular, the natural history of parasites at this location is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 21 patients with vesicular extraparenchymal NCC who had not received treatment for at least 18\u00a0months. We collected their demographic and clinical data, compared their imaging studies at the beginning and the end of the period without treatment and classified the patients, taking into account the evolution of their parasitic burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 men and 11 women were included. Patients had undergone a period of 63\u00b148\u00a0months without treatment. During this period, 8 patients (38.1%) showed an increase, 7 (33.3%) a decrease and 6 (28.6%) showed no change in parasite burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The natural history of extraparenchymal cysticerci is heterogeneous. The results show the ability of parasites to survive for a long time in the extraparenchymal location and explain the chronicity of the disease in some patients. The links between these findings and the difficulties in the therapeutic management of extraparenchymal NCC patients should be studied.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/traa174","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T16:58:05Z","timestamp":1608224285000},"page":"1218-1225","source":"Crossref","is-referenced-by-count":8,"title":["Natural history of extraparenchymal neurocysticercosis"],"prefix":"10.1093","volume":"115","author":[{"given":"Ilse","family":"Murrieta","sequence":"first","affiliation":[{"name":"Neurocysticercosis Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Flores","sequence":"additional","affiliation":[{"name":"Neurocysticercosis Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Osorio","sequence":"additional","affiliation":[{"name":"Neurocysticercosis Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kuschick Feher","sequence":"additional","affiliation":[{"name":"Neurocysticercosis Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Carrillo-Mezo","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-2202","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Fleury","sequence":"additional","affiliation":[{"name":"Neurocysticercosis Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"},{"name":"Neuroinflammation Unit, Instituto de Investigaciones Biom\u00e9dicas-Universidad Nacional Aut\u00f3noma de M\u00e9xico\/INNN\/Facultad de Medicina-UNAM, Ciudad de M\u00e9xico CP 14269, M\u00e9xico"},{"name":"Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental department, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional \u00daut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Apartado postal 70228, Ciudad de M\u00e9xico 04510, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"2021100202532281800_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11908-014-0437-6","article-title":"Neurocysticercosis: an update","volume":"16","author":"Coyle","year":"2014","journal-title":"Curr Infect Dis Rep"},{"issue":"6","key":"2021100202532281800_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0005646","article-title":"Extraparenchymal neurocysticercosis: demographic, clinicoradiological, and inflammatory features","volume":"11","author":"Marcin Sierra","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"issue":"1","key":"2021100202532281800_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/MAJ.0b013e31823e6565","article-title":"Extraparenchymal neurocysticercosis in the United States","volume":"344","author":"Kelesidis","year":"2012","journal-title":"Am J Med Sci."},{"issue":"3","key":"2021100202532281800_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/pim.12299","article-title":"Immunopathology in Taenia solium neurocysticercosis","volume":"38","author":"Fleury","year":"2016","journal-title":"Parasite Immunol"},{"issue":"11","key":"2021100202532281800_bib5","doi-asserted-by":"crossref","first-page":"e0005115","DOI":"10.1371\/journal.pntd.0005115","article-title":"Clinical symptoms, imaging features and cyst distribution in the cerebrospinal fluid compartments in patients with extraparenchymal neurocysticercosis","volume":"10","author":"Bazan","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"2021100202532281800_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actatropica.2015.08.017","article-title":"Relevance of 3D magnetic resonance imaging sequences in diagnosing basal subarachnoid neurocysticercosis","volume":"152","author":"Carrillo Mezo","year":"2015","journal-title":"Acta Trop"},{"issue":"11","key":"2021100202532281800_bib7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1365-3156.1999.00477.x","article-title":"Treating neurocysticercosis medically: a systematic review of randomized, controlled trials","volume":"4","author":"Salinas","year":"1999","journal-title":"Trop Med Int. 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