{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:38Z","timestamp":1740138578484,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008532","name":"UFRN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently syphilis is considered an epidemic disease worldwide. The objective of this study was to identify intra-urban differentials in the occurrence of congenital and acquired syphilis and syphilis in pregnant women in the city of Natal, in northeast Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of syphilis recorded by the municipal surveillance system from 1 January 2011 to 30 December 2018 were analysed. Spatial statistical analyses were performed using the kernel density estimator of the quadratic smoothing function (weighted). SaTScan software was applied for the calculation of risk based on a discrete Poisson model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 2163 cases of acquired syphilis, 738 cases of syphilis in pregnant women and 1279 cases of congenital syphilis. Kernel density maps showed that the occurrence of cases is more prevalent in peripheral areas and in areas with more precarious urban infrastructure. In 2011\u20132014 and 2015\u20132018, seven statistically significant clusters of acquired syphilis were identified. From 2011 to 2014, the most likely cluster had a relative risk of 3.54 (log likelihood ratio [LLR] 38\u00a0895; p&amp;lt;0.001) and from 2015 to 2018 the relative risk was 0.54 (LLR 69\u00a0955; p&amp;lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the municipality of Natal, there was a clustered pattern of spatial distribution of syphilis, with some areas presenting greater risk for the occurrence of new cases.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trab011","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:46:32Z","timestamp":1610671592000},"page":"1010-1018","source":"Crossref","is-referenced-by-count":2,"title":["Intra-urban differentials of congenital and acquired syphilis and syphilis in pregnant women in an urban area in northeastern Brazil"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-6626","authenticated-orcid":false,"given":"Talita Araujo","family":"de Souza","sequence":"first","affiliation":[{"name":"Health Sciences Postgraduate Program, Federal University Of Rio Grande do Norte, Natal, Rio Grande do Norte 59056-150, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Kaline","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Health Surveillance Department, Municipal Health Secretary, Natal, Rio Grande do Norte 59025-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginaldo Lopes","family":"Santana","sequence":"additional","affiliation":[{"name":"Health Surveillance Department, Municipal Health Secretary, Natal, Rio Grande do Norte 59025-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia Barros","family":"Penha","sequence":"additional","affiliation":[{"name":"Health Surveillance Department, Municipal Health Secretary, Natal, Rio Grande do Norte 59025-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur de Almeida","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Integrated Health Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil"},{"name":"Public Health Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59056-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5668-4398","authenticated-orcid":false,"given":"Kenio Costa","family":"de Lima","sequence":"additional","affiliation":[{"name":"Public Health Postgraduate Program, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59056-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-2849","authenticated-orcid":false,"given":"Isabelle Ribeiro","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Public Health Postgraduate 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