{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:07:32Z","timestamp":1789578452936,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Regional Medical Research Centre"},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute encephalitis syndrome (AES) is a major public health concern in India, causing febrile illness principally associated with viral infection. Bacteria-like scrub typhus and leptospirosis also cause acute febrile illness. Therefore, this study was conceived to address the possible etiological agents contributing to sporadic AES in a tertiary care center in Odisha, India.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>This was a prospective hospital-based study that enrolled 92 consecutive patients with clinically diagnosed AES whose blood\/cerebrospinal fluid samples were tested for IgM antibodies to dengue, Japanese encephalitis (JE), herpes simplex virus (HSV), Epstein-Barr virus (EBV), leptospirosis and scrub typhus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Viral antibodies to dengue were detected in three (3.26%) cases, HSV1 in four (4.34%) and HSV2 in three (3.26%) cases. Significantly, antibodies to EBV in 22 (23.591%) and to JE in 27 (29.34%) cases were detected. Notably, 30 (32.60%) and 11(12.0%) of patients had IgM antibodies to leptospirosis and scrub typhus, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This observation indicates an association of leptospirosis and scrub typhus infection in sporadic cases of AES, besides other viruses.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trab063","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T19:14:44Z","timestamp":1617131684000},"page":"1088-1090","source":"Crossref","is-referenced-by-count":12,"title":["Association of leptospirosis and scrub typhus in acute encephalitis syndrome in a tertiary care hospital in Odisha, India"],"prefix":"10.1093","volume":"115","author":[{"given":"Bidyut Kumar","family":"Das","sequence":"first","affiliation":[{"name":"Department of Medicine, SCB Medical College & Hospital, Manglabag, Cuttack 753007, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriprasad","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Medicine, SCB Medical College & Hospital, Manglabag, Cuttack 753007, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash Kumar","family":"Sahoo","sequence":"additional","affiliation":[{"name":"ICMR-Regional Medical Research Centre, Bhubaneswar 751023, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"2021090403104178500_bib1","first-page":"18","article-title":"Investigation of an outbreak of Japanese encephalitis in Rourkela city (Orissa) during 1989","volume":"23","author":"Vajpayee","year":"1991","journal-title":"J Commu Dis"},{"key":"2021090403104178500_bib2","article-title":"Leptospirosis - 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