{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:45:52Z","timestamp":1771530352630,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We analysed the spatial distribution and the socio-economic and environmental factors (SEFs) associated with Schistosoma mansoni infection in the state of Alagoas, an important tourist area in northeastern Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an ecological time-series study (2007\u20132016) on schistosomiasis cases and SEFs. We evaluated the temporal trends of schistosomiasis cases (annual percentage change [APC]) and their correlation with SEFs. Spatial analysis maps were built using QGIS and TerraView software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed that 4.9% of the municipalities had a high prevalence of S. mansoni infection and were located mainly in the coastal strip of Alagoas state. The positivity rate for schistosomiasis decreased during the period (8.1% in 2007 to 4.9% in 2016; APC=\u22125.71). There was a reduction in the number of tests performed (APC=\u22125.05). There was a negative correlation between S. mansoni infection and the municipal human development index (\u03c1=\u22120.34) and schooling rate (\u03c1=\u22120.24). The main species of snail was Biomphalaria glabrata (94.79%), but Biomphalaria straminea showed a higher percentage of S. mansoni detection (10.11%). Lastly, Biomphalaria tenagophila specimens were identified for the first time in Alagoas (n=28).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite a reduction in the number of cases, intestinal schistosomiasis still represents a serious public health concern in Alagoas. It urgently requires planning and improvements in diagnosis, prevention programs and the state's socio-economic indicators.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trab090","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T20:54:22Z","timestamp":1622667262000},"page":"108-116","source":"Crossref","is-referenced-by-count":6,"title":["Risk clusters of <i>Schistosoma mansoni<\/i> infection in an endemic state of Brazil: space\u2013time modelling and association with socio-economic and environmental factors"],"prefix":"10.1093","volume":"116","author":[{"given":"Mariana do Ros\u00e1rio","family":"Souza","sequence":"first","affiliation":[{"name":"Parasitic Biology Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damyres Menezes S","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Parasitic Biology Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexrangel H Cruz","family":"Santos","sequence":"additional","affiliation":[{"name":"Parasitic Biology Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-0742","authenticated-orcid":false,"given":"Shirley V M Almeida","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Nursing, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil"},{"name":"Post Graduate Program of Nursing, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-1887","authenticated-orcid":false,"given":"Allan","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Nursing, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil"},{"name":"Post Graduate Program of Nursing, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora dos Santos","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Health Education, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Concei\u00e7\u00e3o G M","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Parasitic Biology Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Department of Morphology, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-6537","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Bezerra-Santos","sequence":"additional","affiliation":[{"name":"Parasitic Biology Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Department of Morphology, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil"},{"name":"Immunology and Molecular Biology Laboratory, University Hospital, Universidade Federal de Sergipe, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"issue":"50","key":"2022031008061108400_bib1","first-page":"681","article-title":"Schistosomiasis and soil-transmitted helminthiases: numbers of people treated in 2017","volume":"93","author":"World Health Organization","year":"2018","journal-title":"Wkly Epidemiol Rec"},{"issue":"3","key":"2022031008061108400_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1590\/0037-8682-0411-2016","article-title":"Spatial analysis of viral hepatitis and schistosomiasis coinfection in an endemic area in northeastern Brazil","volume":"50","author":"Santos","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"key":"2022031008061108400_bib3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1590\/0037-8682-0137-2016","article-title":"Spatial analysis for the identification of risk areas for schistosomiasis mansoni in the state of Sergipe, Brazil, 2005\u20132014","volume":"49","author":"Santos","year":"2016","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"2022031008061108400_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/trstmh\/traa202","article-title":"Disruptions to schistosomiasis programmes due to COVID-19: an analysis of potential impact and mitigation strategies","volume":"115","author":"Kura","year":"2021","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2022031008061108400_bib5","doi-asserted-by":"crossref","first-page":"105668","DOI":"10.1016\/j.actatropica.2020.105668","article-title":"Spatiotemporal clusters of schistosomiasis mortality and association with social determinants of health in the Northeast region of Brazil (1980\u20132017)","volume":"212","author":"Paz","year":"2020","journal-title":"Acta Trop"},{"key":"2022031008061108400_bib6","volume-title":"Inqu\u00e9rito Nacional de Preval\u00eancia Da Esquistossomose Mansoni e Geo-Helmintoses","author":"Katz","year":"2018","edition":"1st ed."},{"issue":"1","key":"2022031008061108400_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s40249-017-0299-x","article-title":"Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province, Peoples\u2019 Republic of China using a geographical detector method","volume":"6","author":"Hu","year":"2017","journal-title":"Infect Dis Poverty"},{"issue":"6","key":"2022031008061108400_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/trstmh\/traa115","article-title":"A cross-sectional survey of the knowledge, attitudes and practices regarding schistosomiasis among rural schoolchildren in Taiz governorate, southwestern Yemen","volume":"115","author":"Alharazi","year":"2021","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2022031008061108400_bib9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1186\/s12889-019-7224-0","article-title":"Spatial and temporal analysis of tuberculosis in an area of social inequality in Northeast Brazil","volume":"19","author":"Lima","year":"2019","journal-title":"BMC Public Health"},{"issue":"7","key":"2022031008061108400_bib10","doi-asserted-by":"crossref","first-page":"e023420","DOI":"10.1136\/bmjopen-2018-023420","article-title":"Clinical and epidemiological indicators and spatial analysis of leprosy cases in patients under 15 years old in an endemic area of Northeast Brazil: an ecological and time series study","volume":"9","author":"Santos","year":"2019","journal-title":"BMJ Open"},{"issue":"5","key":"2022031008061108400_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1590\/S0037-86822012000500017","article-title":"Spatial distribution of schistosomiasis and geohelminthiasis cases in the rural areas of Pernambuco, Brazil","volume":"45","author":"Barbosa","year":"2012","journal-title":"Rev Soc Bras Med Trop"},{"issue":"2","key":"2022031008061108400_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/1519-6984.190291","article-title":"Achatina fulica (Gastropoda: Pulmonata): occurrence, environmental aspects and presence of nematodes in Sergipe, Brazil","volume":"80","author":"Silva","year":"2020","journal-title":"Braz J Biol"},{"issue":"2","key":"2022031008061108400_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1590\/S0102-311X2007000200017","article-title":"Spatial analysis of Biomphalaria glabrata foci and human cases of mansoni schistosomiasis in Porto de Galinhas, Pernambuco State, Brazil, in the year 2000]","volume":"23","author":"Concei\u00e7\u00e3o","year":"2007","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"2022031008061108400_bib14","volume-title":"Brasil","author":"IBGE"},{"key":"2022031008061108400_bib15","article-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis","volume-title":"Vigil\u00e2ncia da esquistossomose mans\u00f4nica: diretrizes t\u00e9cnicas","author":"Brasil","year":"2014","edition":"4a. ed."},{"issue":"3","key":"2022031008061108400_bib16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5123\/S1679-49742015000300024","article-title":"Using time series analysis in epidemiological studies","volume":"24","author":"Antunes","year":"2015","journal-title":"Epidemiol Serv Sa\u00fade"},{"key":"2022031008061108400_bib17","doi-asserted-by":"crossref","first-page":"e68336","DOI":"10.1371\/journal.pone.0068336","article-title":"New approaches for calculating Moran's index of spatial autocorrelation","volume":"8(7)","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2022031008061108400_bib18","first-page":"360","article-title":"Spatial analysis of the prevalence of schistosomiasis in an endemic coastal area in north-eastern Brazil","volume":"12","author":"Santos","year":"2017","journal-title":"Geospat Health"},{"issue":"2","key":"2022031008061108400_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/trstmh\/traa167","article-title":"Medicine donation programmes supporting the global drive to end the burden of neglected tropical diseases","volume":"115","author":"Bradley","year":"2021","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"2022031008061108400_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0102-311X2007000100025","article-title":"An\u00e1lise preliminar do Sistema de Informa\u00e7\u00e3o do Programa de Controle da Esquistossomose no per\u00edodo de 1999 a 2003 Preliminary analysis of the Information System in the Brazilian Schistosomiasis Control Program","volume":"23","author":"Maria","year":"2007","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"7","key":"2022031008061108400_bib21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"2022031008061108400_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/trstmh\/traa082","article-title":"Hepatosplenic schistosomiasis, the ignored morbidity: experience from a referral hospital in Ethiopia","volume":"115","author":"Abdela","year":"2021","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"2022031008061108400_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S0037-86822011000100020","article-title":"Aspectos epidemiol\u00f3gicos e distribui\u00e7\u00e3o geogr\u00e1fca da esquistossomose e geo-helmintos, no estado de Sergipe, de acordo com os dados do programa de controle da esquistossomose","volume":"44","author":"Rollemberg","year":"2011","journal-title":"Rev Soc Bras Med Trop"},{"key":"2022031008061108400_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.actatropica.2015.04.024","article-title":"School-based and community-based actions for scaling-up diagnosis and treatment of schistosomiasis toward its elimination in an endemic area of Brazil","volume":"149","author":"Favre","year":"2015","journal-title":"Acta Trop"},{"issue":"7","key":"2022031008061108400_bib25","doi-asserted-by":"crossref","first-page":"e004794","DOI":"10.1371\/journal.pntd.0004794","article-title":"Global assessment of schistosomiasis control over the past century shows targeting the snail intermediate host works best","volume":"10","author":"Sokolow","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2022031008061108400_bib26","doi-asserted-by":"crossref","first-page":"105897","DOI":"10.1016\/j.actatropica.2021.105897","article-title":"Population-based, spatiotemporal modeling of social risk factors and mortality from schistosomiasis in Brazil between 1999 and 2018","volume":"218","author":"Silva da Paz","year":"2021","journal-title":"Acta Trop"},{"issue":"4","key":"2022031008061108400_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1590\/S0037-86822005000400004","article-title":"Esquistossomose mansoni em duas mesorregi\u00f5es do Estado de Alagoas Schistosomiasis mansoni in two mesoregions of the State of Alagoas","volume":"38","author":"Couto","year":"2005","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"2022031008061108400_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/S0037-86822010000300020","article-title":"Preval\u00eancia da infec\u00e7\u00e3o pelo Schistosoma mansoni em dois munic\u00edpios do Estado de Alagoas","volume":"43","author":"Palmeira","year":"2010","journal-title":"Rev Soc Bras Med Trop"},{"issue":"Suppl","key":"2022031008061108400_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S0074-02762001000900002","article-title":"The schistosome vectors in the Americas","volume":"96","author":"Paraense","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"5","key":"2022031008061108400_bib30","doi-asserted-by":"crossref","first-page":"e0004546","DOI":"10.1371\/journal.pntd.0004546","article-title":"Socioeconomic inequalities in neglected tropical diseases: a systematic review","volume":"10","author":"Houweling","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"2022031008061108400_bib31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1590\/S0102-311X2013000200022","article-title":"Biological and environmental factors associated with risk of schistosomiasis mansoni transmission in Porto de Galinhas, Pernambuco State, Brazil","volume":"29","author":"Andrade","year":"2013","journal-title":"Cad. Sa\u00fade P\u00fablica"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/2\/108\/42793776\/trab090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/2\/108\/42793776\/trab090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T08:09:01Z","timestamp":1646899741000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/116\/2\/108\/6301126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,16]]},"published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trab090","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2]]},"published":{"date-parts":[[2021,6,16]]}}}