{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T10:03:49Z","timestamp":1720433029758},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a paucity of predictive factors for early recovery from thrombocytopenia related to dengue. The immature platelet fraction (IPF%) is reflective of megakaryopoiesis and may correlate with recovery from dengue-related thrombocytopenia. Our objective was to assess the predictive value of IPF% on days 2 and 3 of illness for recovery from dengue-related thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted among patients with dengue admitted to our institution (Nawaloka Hospital PLC) from December 2019 to October 2020. Dengue was diagnosed based on positive non-structural antigen 1 or IgM. IPF% data were extracted from the Sysmex-XN-1000 automated hematology analyzer. Clinical data were obtained from electronic medical records. Statistical analyses were performed using SPSS version 20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 240 patients. An IPF% on day 2 of illness of &amp;gt;7.15% had a sensitivity of 80.0% and specificity of 70.4% for prediction of platelet recovery (defined as platelet count \u226560\u00d7109\/L) on day 7 of illness. An IPF% of &amp;gt;7.25% on day 3 of illness had a sensitivity of 88.9% and specificity of 47.1% for predicting platelet recovery &amp;gt;60\u00d7109\/L on day 8 of illness. The IPF% was significantly lower in patients with severe dengue. Platelet recovery was observed within 48 h after the peak IPF% was reached, regardless of severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose that IPF% values on days 2 and 3 of illness are a promising predictive tool for early recovery from dengue-related thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trab135","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:31:18Z","timestamp":1631100678000},"page":"424-432","source":"Crossref","is-referenced-by-count":2,"title":["The immature platelet fraction, a predictive tool for early recovery from dengue-related thrombocytopenia: a prospective study"],"prefix":"10.1093","volume":"116","author":[{"given":"Visula","family":"Abeysuriya","sequence":"first","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo 00200, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suranjith L","family":"Seneviratne","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo 00200, Sri Lanka"},{"name":"Institute of Immunity and Transplantation, Royal Free Hospital and University College London, London NW3 2QG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primesh","family":"de Mel","sequence":"additional","affiliation":[{"name":"Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals PLC, Colombo 00200, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong Shi Hui","family":"Clarice","sequence":"additional","affiliation":[{"name":"Department of Haematology - 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