{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:23:29Z","timestamp":1790400209132,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malnutrition is a leading cause of morbidity and mortality in children aged &amp;lt;5 y, especially in low- and middle-income countries (LMICs). Unlike severe acute malnutrition, moderate acute malnutrition (MAM) affects greater numbers globally, and guidelines lack a robust evidence base. This systematic review and meta-analysis assessed the evidence for lipid-based nutrient supplements (LNSs), fortified blended flours (FBFs) and nutrition counselling, in the treatment of MAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases were systematically searched for studies conducted in LMICs that compared the effectiveness of food-based products with any comparator group in promoting recovery from MAM in children aged 6-59 mo. Where appropriate, pooled estimates of effect were estimated using random-effects meta-analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13 trials were identified for inclusion. All used active controls. There was evidence of increased probability of recovery (gaining normal weight-for-height and\/or mid-upper arm circumference) among children treated with LNSs compared with children treated with FBFs (risk ratio 1.05, 95% CI 1.01 to 1.09, p=0\u00b7009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on a relatively small number of studies mainly from Africa, LNSs are superior to FBFs in improving anthropometric recovery from MAM. Current evidence for the use of food supplements in MAM treatment is based on comparisons with active controls. Future studies should assess a wider range of comparator groups, such as nutrition education\/counselling alone, and outcomes, including body composition, morbidity and development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trab137","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T07:31:18Z","timestamp":1631086278000},"page":"1317-1329","source":"Crossref","is-referenced-by-count":5,"title":["The management of moderate acute malnutrition in children aged 6-59 months in low- and middle-income countries: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"115","author":[{"given":"Imara","family":"Gluning","sequence":"first","affiliation":[{"name":"Department of Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"},{"name":"Brighton and Sussex University Hospitals Trust, Brighton, BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Kerac","sequence":"additional","affiliation":[{"name":"Department of Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"},{"name":"Centre for MARCH (Maternal, Reproductive, Adolescent & Child Health Centre), London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"},{"name":"International Rescue Committee, New York, NY, 10168-1289, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amela","family":"Bander","sequence":"additional","affiliation":[{"name":"Department of Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Opondo","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK"},{"name":"National Perinatal Epidemiology Unit, University of Oxford, Oxford, OX3 7LF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"2021110203050668000_bib1","article-title":"World Health Organization, International Bank for Reconstruction and Development\/The World Bank","author":"United Nations Children\u2019s Fund (UNICEF)","year":"2020","journal-title":"Levels and trends in child malnutrition: Key Findings of the 2020 Edition of the Joint Child Malnutrition Estimates"},{"issue":"9890","key":"2021110203050668000_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","article-title":"Maternal and child 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