{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:21:33Z","timestamp":1783164093249,"version":"3.54.6"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Autochthonous human infections with Strongyloides stercoralis have been well documented in many European regions. By exploring patients\u2019 data, we aimed to find elements for its current endemicity in Croatia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective descriptive study analysed epidemiological and clinical data of patients treated for strongyloidiasis from January 2010 to May 2019 at a teaching hospital in Zagreb, Croatia. The diagnosis was made by direct methods using light microscopy and\/or serology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 65 patients with strongyloidiasis, 60% were men, and 78.5% were 50\u201379\u00a0y of age. The sensitivity of the examination of three stool samples after concentration, saline provocation and serology was 26.2, 80.7 and 86.2%, respectively. Clinical presentation included asymptomatic patients with eosinophilia (41.5%), chronic symptomatic infection (33.8%), acute infection (18.5%) and hyperinfection (6.2%). Twenty patients (30.8%) were immunosuppressed; among four of whom developed hyperinfection, two died. Initially 71.7% of patients were treated with albendazole and 13.3% with ivermectin, with an equal parasitological cure rate (72.2% and 75%; p=0.09). In 11 patients, acute infection was autochthonous in its origin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Strongyloidiasis is currently endemic in Croatia and immunosuppressed travellers to this region should be advised to take precautions. Patients undergoing immunosuppression and organ donors from Croatia should be screened.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trab139","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:31:18Z","timestamp":1631100678000},"page":"1298-1303","source":"Crossref","is-referenced-by-count":6,"title":["Is strongyloidiasis currently autochthonous in Croatia? A retrospective study"],"prefix":"10.1093","volume":"115","author":[{"given":"Mirjana","family":"Balen Topi\u0107","sequence":"first","affiliation":[{"name":"University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevi\u0107\u201d, Mirogojska 8, 10000 Zagreb, Croatia"},{"name":"University of Zagreb, School of Medicine, \u0160alata 3b, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ena","family":"Marjanovi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevi\u0107\u201d, Mirogojska 8, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domagoj","family":"Tomasovi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevi\u0107\u201d, Mirogojska 8, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sviben","sequence":"additional","affiliation":[{"name":"University of Zagreb, School of Medicine, \u0160alata 3b, 10000 Zagreb, Croatia"},{"name":"Croatian Institute of Public Health, Department for Parasitology and Mycology, Rockefellerova 7, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"issue":"6","key":"2021110203050240300_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3390\/pathogens9060439","article-title":"Autochthonous human and canine Strongyloides stercoralis infection in Europe: report of a human case in an Italian teen and systematic review of the literature","volume":"9","author":"Ottino","year":"2020","journal-title":"Pathogens"},{"issue":"7","key":"2021110203050240300_bib2","doi-asserted-by":"crossref","first-page":"e2288","DOI":"10.1371\/journal.pntd.0002288","article-title":"Strongyloides stercoralis: global distribution and risk factors","volume":"7","author":"Sch\u00e4r","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"2021110203050240300_bib3","first-page":"43","article-title":"[Strongyloidosis in northwestern Croatia. 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