{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:37:22Z","timestamp":1790195842330,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The S\u00e3o Tom\u00e9 e Pr\u00edncipe government is committed to achieving neglected tropical disease (NTD) control and elimination as a public health problem by 2025. In 2014, the Ministry of Health led a national survey to determine the prevalence of soil-transmitted helminths (STHs) and schistosomiasis across the country. Following this survey, a preventive chemotherapy (PC) campaign with mebendazole and praziquantel reached 31\u2009501 school-age children in 2015. A follow-up 2017 survey to determine the impact of the intervention showed success in controlling schistosomiasis, as no infections were found, but limited impact on STHs, with prevalence similar to pretreatment levels. The survey also investigated the prevalence of a third NTD, lymphatic filariasis (LF), which was found to be endemic in the country. Since then the Ministry of Health has developed the Strategic Plan for the Fight Against Neglected Tropical Diseases 2019\u20132025 and identified gaps to be addressed. This narrative review systematises the existing literature reporting on the epidemiology of NTDs for which there are PC programs in S\u00e3o Tom\u00e9 e Pr\u00edncipe. PubMed was searched for relevant papers that measured the prevalence of LF, schistosomiasis and STHs. Additionally, data provided by the Ministry of Health surveys were analysed. Finally, we discuss current NTD control, including the impact of the coronavirus disease 2019 pandemic and identify priorities for program strengthening and operational research.<\/jats:p>","DOI":"10.1093\/trstmh\/trab153","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T12:49:56Z","timestamp":1633610996000},"page":"446-453","source":"Crossref","is-referenced-by-count":2,"title":["Progress towards control and elimination of neglected tropical diseases targeted by preventive chemotherapy in S\u00e3o Tom\u00e9 e Pr\u00edncipe"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-1989","authenticated-orcid":false,"given":"Aisling","family":"Byrne","sequence":"first","affiliation":[{"name":"Kirby Institute, University of New South Wales, Sydney, NSW 1466, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzira","family":"Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Programa de Controlo de Doen\u00e7as Tropicais Negligenciadas, Minist\u00e9rio da Sa\u00fade, Rua Patrice Lumumba, S\u00e3o Tom\u00e9, S\u00e3o Tom\u00e9 & Pr\u00edncipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"da Concei\u00e7\u00e3o Ferreira","sequence":"additional","affiliation":[{"name":"World Health Organization\/European Society for Clinical Nutrition and Metabolism"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Jesus Trovoada dos Santos","sequence":"additional","affiliation":[{"name":"Programa de Controlo de Doen\u00e7as Tropicais Negligenciadas, Minist\u00e9rio da Sa\u00fade, Rua Patrice Lumumba, S\u00e3o Tom\u00e9, S\u00e3o Tom\u00e9 & Pr\u00edncipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rollinson","sequence":"additional","affiliation":[{"name":"Global Schistosomiasis Alliance, Natural History Museum, London SW7\u00a05BD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vaz Nery","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales, Sydney, NSW 1466, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"issue":"10066","key":"2022050515141061900_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(16)30171-4","article-title":"Neglected tropical diseases: progress towards addressing the chronic pandemic","volume":"21","author":"Molyneux","year":"2017","journal-title":"Lancet"},{"key":"2022050515141061900_bib2","author":"World Health Organization","year":"2012","journal-title":"Accelerating work to overcome the global impact of neglected tropical diseases \u2013 a roadmap for implementation"},{"key":"2022050515141061900_bib3","volume-title":"Preventive chemotherapy and transmission control (PCT)","author":"World Health Organization","year":"2015"},{"key":"2022050515141061900_bib4","volume-title":"2030 targets for soil-transmitted helminthiases control programmes","author":"World Health Organization","year":"2020"},{"key":"2022050515141061900_bib5","volume-title":"The strategic plan for the fight against neglected tropical diseases 2019-2025","author":"Minist\u00e9rio da Sa\u00fade - S\u00e3o Tom\u00e9 e Pr\u00edncipe","year":"2019"},{"key":"2022050515141061900_bib6","volume-title":"Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030","author":"World Health Organization","year":"2020"},{"key":"2022050515141061900_bib7","author":"Minist\u00e9rio da Sa\u00fade - S\u00e3o Tom\u00e9 e Pr\u00edncipe","year":"2019","journal-title":"Plano operacional"},{"key":"2022050515141061900_bib8","volume-title":"Situation Epidemiologique des MTN a S\u00e3o Tom\u00e9 e Pr\u00edncipe","author":"Minist\u00e9rio da Sa\u00fade - S\u00e3o Tom\u00e9 e Pr\u00edncipe","year":"2019"},{"key":"2022050515141061900_bib9","first-page":"15","article-title":"Human intestinal parasites in Subsaharan Africa. 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