{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:43:18Z","timestamp":1773171798749,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Instituto de Virolog\u00ed"},{"name":"Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study is to show that human T-cell lymphotropic virus type 2 (HTLV-2) infection produces symptoms resembling those described for HTLV-1-associated myeloneuropathy and to highlight the role of sexual transmission in the silent dissemination of HTLV-2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patient samples were tested by particle agglutination and indirect immunofluorescence assay. The HTLV type was defined by molecular techniques. Nucleotide sequence analysis of HTLV-2 long terminal repeat region, T cell CD3\/CD4 and T cell CD3\/CD8 counts and typing of human leucocyte antigen (HLA) alleles A, B, C and DRB1 were also performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>HTLV-2 subtype b infection was confirmed in two blood donors and their sexual partners. Two patients exhibited distinctive signs and symptoms of progressive neurological disease. Three infected patients carried HLA-C*04. Both patients with neurological disease also carried HLA-A*31 and HLA-DRB1*07 alleles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Herein we describe for the first time sexual transmission of HTLV-2 in a non-endemic region of Argentina, highlighting the relevance of this transmission route in HTLV-2 silent dissemination out of the clusters of endemicity. We also provide evidence that HTLV-2 infection causes symptoms resembling those described for HTLV-1-associated myeloneuropathy. The evidence presented herein points to the critical need for public health strategies to reduce the spread of this neglected infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trab173","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T23:13:10Z","timestamp":1634944390000},"page":"622-627","source":"Crossref","is-referenced-by-count":12,"title":["Neurodegenerative disease in association with sexual transmission of human T-cell lymphotropic virus type 2 subtype b in Argentina"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-2833","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Blanco","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre , C\u00f3rdoba, 5000, Argentina"},{"name":"Instituto de Virolog\u00eda Dr J M Vanella, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Barile","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Cl\u00ednica M\u00e9dica I, Hospital Misericordia , C\u00f3rdoba, 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Celia","family":"Frutos","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda Dr J M Vanella, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba, 5000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Paulo","family":"Vicente","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute , FIOCRUZ, Rio de Janeiro, 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Ver\u00f3nica","family":"Gallego","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Banco Central de Sangre , C\u00f3rdoba, 5000, 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