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We searched bibliographic databases from dates of inception to November 2020, yielding 28 included studies.<\/jats:p>\n                  <jats:p>The absolute risk of maternal death associated with EVD was estimated at 67.8% (95% confidence interval [CI] 49.8 to 83.7, I2=85%, p&amp;lt;0.01) and the relative risk of death in pregnant women compared with non-pregnant women was estimated at 1.18 (95% CI 0.59 to 2.35, I2=31.0%, p=0.230). The absolute risk for foetal losses was estimated at 76.9% (95% CI 45.0 to 98.3, I2=96%, p&amp;lt;0.01) and neonatal death was 98.5% (95% CI 84.9 to 100, I2=0.0%, p=0.40). The gap analysis suggests limited or no data on the clinical course, non-fatal perinatal outcomes and EVD management in pregnant women. The review suggests that EVD has a high maternal and perinatal mortality, underscoring the urgent need for preventative and therapeutic solutions and improved screening and follow-up of pregnant women and newborns during outbreaks. There is not enough evidence to conclusively rule out pregnancy as a risk factor for mortality and there is limited evidence on the disease course, outcomes and management of EVD in pregnancy, and this supports the need for robust clinical trials and prospective studies that include pregnant women.<\/jats:p>","DOI":"10.1093\/trstmh\/trab180","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T15:16:10Z","timestamp":1636470970000},"page":"509-522","source":"Crossref","is-referenced-by-count":26,"title":["Ebola virus disease in pregnancy: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3312","authenticated-orcid":false,"given":"Nzelle D","family":"Kayem","sequence":"first","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford , Oxford OX3 7LG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-1049","authenticated-orcid":false,"given":"Charlotte","family":"Benson","sequence":"additional","affiliation":[{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals , Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-6740","authenticated-orcid":false,"given":"Christina Y L","family":"Aye","sequence":"additional","affiliation":[{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals , Oxford OX3 9DU, UK"},{"name":"Nuffield Department of Women's and Reproductive Health, University of Oxford , Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-7694","authenticated-orcid":false,"given":"Sarah","family":"Barker","sequence":"additional","affiliation":[{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals , Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-4161","authenticated-orcid":false,"given":"Mariana","family":"Tome","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health, University of Oxford , Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-9317","authenticated-orcid":false,"given":"Stephen","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health, University of Oxford , Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-2237","authenticated-orcid":false,"given":"Proochista","family":"Ariana","sequence":"additional","affiliation":[{"name":"Nuffield , Oxford OX3 7LG, UK"},{"name":"Department of Medicine, University of Oxford , Oxford OX3 7LG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-1586","authenticated-orcid":false,"given":"Peter","family":"Horby","sequence":"additional","affiliation":[{"name":"Nuffield , Oxford OX3 7LG, UK"},{"name":"Department of Medicine, University of Oxford , Oxford OX3 7LG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"2022060111123928300_bib1","volume-title":"Ebola virus disease","author":"World Health Organization"},{"key":"2022060111123928300_bib2","doi-asserted-by":"crossref","first-page":"e04395","DOI":"10.7554\/eLife.04395","article-title":"Mapping the zoonotic niche of Ebola virus disease in Africa","volume":"3","author":"Pigott","year":"2014","journal-title":"Elife"},{"issue":"9768","key":"2022060111123928300_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"2022060111123928300_bib4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1186\/s12879-016-2045-6","article-title":"How severe and prevalent are Ebola and Marburg viruses? 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