{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:48:17Z","timestamp":1782168497377,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Thrombocytopenia is a marker of severity in dengue, and its resolution predicts clinical improvement. The objective was to evaluate mean platelet volume (MPV) trajectories as a predictor of platelet count (PC) recovery in dengue patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational, longitudinal and analytical study was conducted at Fundaci\u00f3n Valle del Lili (Cali, Colombia). Patients diagnosed with dengue during 2016\u20132020 were included. The association between PC and the covariates was evaluated using simple linear, quadratic and non-parametric spline smoothing regression models. A longitudinal linear mixed model was adjusted and then validated for PC measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 71 patients were included. The median age was 27 y, 38.5% were women and half had dengue with warning signs. A statistically significant PC decrease was observed when MPV was 13.87 fL and 4.46 d from the onset of symptoms, while PC displayed a significant constant increase with neutrophils count. Then, PC recovery was achieved with an MPV of 13.58 fL, 4.5 d from the onset of symptoms and a minimum neutrophils count of 150 \u03bcL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MPV may be a predictor of PC recovery in dengue patients. PC recovery is expected when a patient has an MPV of 13.58 fL, an onset time of 4.5 d and a neutrophils count of 150 \u03bcL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trac008","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T20:13:40Z","timestamp":1643055220000},"page":"798-806","source":"Crossref","is-referenced-by-count":4,"title":["Mean platelet volume as a predictor of platelet count recovery in dengue patients"],"prefix":"10.1093","volume":"116","author":[{"given":"Diana Marcela","family":"Mart\u00ednez-Ru\u00edz","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Alejandro","family":"Tovar-Rios","sequence":"additional","affiliation":[{"name":"Universidad de Icesi, Escuela de Ciencias de la Educaci\u00f3n, Departamento de Matem\u00e1ticas y Estad\u00edstica , Calle 18 No. 122-135, Cali 760031, Colombia"},{"name":"Universidad del Valle, Facultad de Ingenier\u00eda, Escuela de Estad\u00edstica , Calle 13 No. 100-00, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Valencia-Orozco","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Janeth","family":"Florez-Elvira","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Lucia","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-1117","authenticated-orcid":false,"given":"Luis Gabriel","family":"Parra-Lara","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"},{"name":"Universidad Icesi , Facultad de Ciencias de la Salud, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rosso","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas (CIC) , Cra 98 No. 18 - 49, Cali 760032, Colombia"},{"name":"Universidad Icesi , Facultad de Ciencias de la Salud, Cali 760031, Colombia"},{"name":"Fundaci\u00f3n Valle del Lili, Departamento de Medicina Interna , Servicio de Infectolog\u00eda, Cali, Valle del Cauca, Colombia , Cra 98 No. 18 - 49, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"issue":"1","key":"2022091101234700200_bib1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1186\/1756-0500-5-645","article-title":"Evaluation of the WHO revised criteria for classification of clinical disease severity in acute adult dengue infection","volume":"5","author":"Jayaratne","year":"2012","journal-title":"BMC Res Notes"},{"issue":"8","key":"2022091101234700200_bib2","doi-asserted-by":"crossref","first-page":"e769","DOI":"10.1371\/journal.pntd.0000769","article-title":"Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators","volume":"4","author":"Potts","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"2022091101234700200_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/01.inf.0000258612.26743.10","article-title":"Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study","volume":"26","author":"Srikiatkhachorn","year":"2007","journal-title":"Pediatr Infect Dis J"},{"issue":"6","key":"2022091101234700200_bib4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4269\/ajtmh.1969.18.954","article-title":"Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever","volume":"18","author":"Nimmannitya","year":"1969","journal-title":"Am J Trop Med Hyg"},{"key":"2022091101234700200_bib5","first-page":"12","article-title":"Clinical Diagnosis","volume-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention and control","author":"World Health Organization","year":"1997"},{"issue":"2","key":"2022091101234700200_bib6","first-page":"124","article-title":"Role of red cell and platelet indices as a predictive tool for transfusions in dengue","volume":"2","author":"Kantharaj","year":"2017","journal-title":"Glob J Transfus Med"},{"issue":"12","key":"2022091101234700200_bib7","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1172\/JCI26674","article-title":"The molecular mechanisms that control thrombopoiesis","volume":"115","author":"Kaushansky","year":"2005","journal-title":"J Clin Invest"},{"issue":"10","key":"2022091101234700200_bib8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1742-1241.2009.02070.x","article-title":"The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases","volume":"63","author":"Vizioli","year":"2009","journal-title":"Int J Clin Pract"},{"issue":"2","key":"2022091101234700200_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2015-07-660308","article-title":"Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study","volume":"127","author":"Panova-Noeva","year":"2016","journal-title":"Blood."},{"issue":"4","key":"2022091101234700200_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.thromres.2011.05.007","article-title":"Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study","volume":"128","author":"Demirin","year":"2011","journal-title":"Thromb Res"},{"issue":"1","key":"2022091101234700200_bib11","first-page":"1","article-title":"Correlation of enhancement mean platelet volume (MPV) with","volume":"434","author":"Dewi","year":"2018","journal-title":"IOP Conf Ser Mater Sci Eng"},{"key":"2022091101234700200_bib12","first-page":"185","volume-title":"Mean platelet volume in the patients with dengue hemorrhagic fever","author":"Wiwanitkit","year":"2004;"},{"issue":"46","key":"2022091101234700200_bib13","first-page":"11","article-title":"Manifestaciones cl\u00ednicas y de laboratorio relacionadas con la recuperaci\u00f3n de las plaquetas en el dengue hemorr\u00e1gico","volume":"12","author":"Ron-Guerrero","year":"2010","journal-title":"Med Univ"},{"issue":"11","key":"2022091101234700200_bib14","first-page":"EC01","article-title":"Association of mean platelet volume with severity, serology & treatment outcome in dengue fever: prognostic utility","volume":"9","author":"Sharma","year":"2015","journal-title":"J Clin Diagnostic Res"},{"issue":"6","key":"2022091101234700200_bib15","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.18203\/2320-6012.ijrms20182287","article-title":"Platelet indices evaluation in patients with dengue fever","volume":"6","author":"Mukker","year":"2018","journal-title":"Int J Res Med Sci"},{"issue":"4","key":"2022091101234700200_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.23937\/2643-461X\/1710026","article-title":"Utility of mean platelet volume to predict significant thrombocytopenia and complications in dengue","volume":"2","author":"Anupam","year":"2019","journal-title":"Int J Trop Dis"},{"issue":"9","key":"2022091101234700200_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.4103\/1735-1995.170609","article-title":"Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage","volume":"20","author":"Eminler","year":"2015","journal-title":"J Res Med Sci"},{"key":"2022091101234700200_bib18","volume-title":"Bolet\u00edn Epidemiol\u00f3gico Semanal: semana epidemiol\u00f3gica 26 (21 al 27 de junio de 2020)","author":"Instituto Nacional de Salud (INS)","year":"2020"},{"key":"2022091101234700200_bib19","first-page":"1","volume-title":"Dengue guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization, Special Programme for Research and Training in Tropical Diseases","year":"2009"},{"issue":"4","key":"2022091101234700200_bib20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"2022091101234700200_bib21","volume-title":"nlme: Linear and Nonlinear Mixed Effects Models","author":"Pinheiro","year":"2020"},{"key":"2022091101234700200_bib22","doi-asserted-by":"crossref","first-page":"313842","DOI":"10.1155\/2015\/313842","article-title":"Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators","volume":"2015","author":"de Azeredo","year":"2015","journal-title":"Mediators Inflamm"},{"key":"2022091101234700200_bib23","first-page":"4370834","article-title":"The role of mean platelet volume as a predictor of mortality in critically ill patients: a systematic review and meta-analysis","volume":"2016","author":"Tajarernmuang","year":"2016","journal-title":"Crit Care Res Pract"},{"issue":"3","key":"2022091101234700200_bib24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5455\/2349-3933.ijam20141108","article-title":"How far are the platelet indices mirror image of mechanism of thrombocytopenia-mystery still remains?","volume":"1","author":"Katti","year":"2014","journal-title":"Int J Adv Med"},{"issue":"5\u20136","key":"2022091101234700200_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/095371002220148332","article-title":"Mean platelet volume as an indicator of platelet activation: methodological issues","volume":"13","author":"Park","year":"2002","journal-title":"Platelets"},{"issue":"1","key":"2022091101234700200_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5581\/1516-8484.20120012","article-title":"Dengue: profile of hematological and biochemical dynamics","volume":"34","author":"Azin","year":"2012","journal-title":"Rev Bras Hematol Hemoter."}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/9\/798\/45788081\/trac008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/9\/798\/45788081\/trac008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T01:24:56Z","timestamp":1662859496000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/116\/9\/798\/6537652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,26]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,2,26]]},"published-print":{"date-parts":[[2022,9,10]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trac008","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,2,26]]}}}