{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:52Z","timestamp":1740138592478,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Deposition of Schistosoma mansoni eggs in the brain of patients with hepatosplenic schistosomiasis (HS-SM) is frequent and usually asymptomatic. However, it is questioned whether it could cause seizures. Thus, we investigated the occurrence of seizures in these patients and also searched for parameters associated with this disorder.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a cross-sectional survey, we compared 128 patients with HS-SM with 102 patients with portal hypertension due to compensated chronic hepatic disease of other etiologies. A standardized questionnaire, emphasizing epilepsy-related parameters, was applied to all participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight (6.3%) patients with HS-SM had a history of seizures, whereas this condition was reported by three (2.9%) individuals from the comparison group (p=0.354). None of the variables were associated with the occurrence of seizures, either in univariate or in multivariate analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The frequency of seizures was similar in both study groups. However, it was higher than that described in population-based studies. Thus, we hypothesize that HS-SM individuals may have a higher frequency of seizure. The lack of difference between the two study groups may be explained by the inclusion of cases of HS-MS overlapping other chronic liver diseases in the comparison group, because this finding is relatively common in schistosome-endemic areas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trac012","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T12:30:08Z","timestamp":1643977808000},"page":"704-709","source":"Crossref","is-referenced-by-count":0,"title":["Are seizures associated with neuroschistosomiasis mansoni? An exploratory survey in an endemic area of Brazil"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-2294","authenticated-orcid":false,"given":"Teresa Cristina A","family":"Ferrari","sequence":"first","affiliation":[{"name":"Departmento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"},{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-0431","authenticated-orcid":false,"given":"Ana Elisa M","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-1730","authenticated-orcid":false,"given":"Maria J\u00falia S","family":"Logato","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-2190","authenticated-orcid":false,"given":"Carolina G","family":"Ganzella","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-480X","authenticated-orcid":false,"given":"Rodolfo Ferreira Q","family":"Melo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radiologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-9090","authenticated-orcid":false,"given":"Ana Paula C","family":"Rocha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radiologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-8201","authenticated-orcid":false,"given":"Fernanda A","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-2606","authenticated-orcid":false,"given":"Pedro Ferrari S","family":"Cunha","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-9248","authenticated-orcid":false,"given":"Rog\u00e9rio Augusto P","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"},{"name":"Servi\u00e7o de Radiologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-3491","authenticated-orcid":false,"given":"Luciana C","family":"Faria","sequence":"additional","affiliation":[{"name":"Departmento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"},{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-2152","authenticated-orcid":false,"given":"Guilherme Grossi L","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-4757","authenticated-orcid":false,"given":"Cl\u00e1udia A","family":"Couto","sequence":"additional","affiliation":[{"name":"Departmento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"},{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-6446","authenticated-orcid":false,"given":"Alo\u00edsio S","family":"Cunha","sequence":"additional","affiliation":[{"name":"Departmento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 190, 30130100 Belo Horizonte, MG, Brazil"},{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena 110, 30130100 Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"issue":"1","key":"2022080602500514400_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"77","author":"Chitsulo","year":"2000","journal-title":"Acta Trop"},{"issue":"9541","key":"2022080602500514400_bib2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"2022080602500514400_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-4614-8100-3_6","article-title":"Neuroschistosomiasis","volume-title":"Neglected Tropical Diseases and Conditions of the Nervous System","author":"Ferrari","year":"2014"},{"key":"2022080602500514400_bib4","first-page":"255","article-title":"O envolviemnto do sistema nervoso central na esquistossomose mans\u00f4nica","volume":"3","author":"Queiroz","year":"1974","journal-title":"Rev Patol Trop"},{"issue":"3","key":"2022080602500514400_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/brain\/104.3.621","article-title":"Brain involvement in hepatosplenic schistosomiasis","volume":"104","author":"Pittella","year":"1981","journal-title":"Brain"},{"issue":"4","key":"2022080602500514400_bib6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/brain\/108.4.1023","article-title":"Involvement of the central nervous system in schistosoma mansoni and s. haematobium infection: a review","volume":"108","author":"Scrimgeour","year":"1985","journal-title":"Brain"},{"issue":"5","key":"2022080602500514400_bib7","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4269\/ajtmh.1985.34.898","article-title":"Vascular changes in cerebral schistosomiasis mansoni: a histopathological study of fifteen cases","volume":"34","author":"Pittella","year":"1985","journal-title":"Am J Trop Med Hyg"},{"key":"2022080602500514400_bib8","first-page":"15","article-title":"The relation between involvement of the central nervous system in schistosomiasis mansoni and the clinical forms of the parasitosis: a review","volume":"94","author":"Pittella","year":"1991","journal-title":"J Trop Med Hyg"},{"key":"2022080602500514400_bib9","first-page":"289","article-title":"Frequency of schistosomiasis mansoni, of its clinicopathological forms and of the ectopic locations of the parasite in autopsies in Belo Horizonte, Brazil","volume":"98","author":"Goncalves","year":"1995","journal-title":"J Trop Med Hyg"},{"issue":"1","key":"2022080602500514400_bib10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1750-3639.1997.tb01080.x","article-title":"Neuroschistosomiasis","volume":"7","author":"Pittella","year":"1997","journal-title":"Brain Pathol"},{"issue":"2-3","key":"2022080602500514400_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.actatropica.2008.04.007","article-title":"Clinical characterization of neuroschistosomiais due to schistosoma mansoni and its treatment","volume":"108","author":"Ferrari","year":"2008","journal-title":"Acta Trop"},{"issue":"9","key":"2022080602500514400_bib12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1474-4422(11)70170-3","article-title":"Neuroschistosomiasis: clinical symptoms and pathogenesis","volume":"10","author":"Ferrari","year":"2011","journal-title":"Lancet Neurol"},{"issue":"2-3","key":"2022080602500514400_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.actatropica.2008.02.010","article-title":"Immune response and pathogenesis of neuroschistosomiais mansoni","volume":"108","author":"Ferrari","year":"2008","journal-title":"Acta Trop"},{"key":"2022080602500514400_bib14","article-title":"UNDP\/World Bank\/WHO special programme for research and training in tropical diseases","volume-title":"Ultrasound in schistosomiasis: a practical guide to the standardized use of ultrasonography for the assessment of schistosomiasis-related morbidity: Second International Workshop","author":"Richter","year":"1996"},{"key":"2022080602500514400_bib15","first-page":"276","article-title":"Comite\u00b4de recherche sur l'Epilepsie de l'Institut d'E\u00b4pide\u00b4- miologie Neurologique et de neurologie tropicale de limoges. Questionnaire d'investigation de l'e\u00b4pilepsie dans les pays tropicaux","volume":"93","author":"Preux","year":"2000","journal-title":"Bull Soc Pathol Exot"},{"key":"2022080602500514400_bib16","first-page":"103","article-title":"D\u00e9pistage de l'\u00e9pilepsie en zones tropicales: validation d'un questionnaire en mauritanie","volume":"99","author":"Diagana","year":"2006","journal-title":"Bull Soc Pathol Exot"},{"issue":"8","key":"2022080602500514400_bib17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"issue":"4","key":"2022080602500514400_bib18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"issue":"4","key":"2022080602500514400_bib19","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League against Epilepsy: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"2022080602500514400_bib20","first-page":"124","article-title":"Prevalence of epilepsy in a Brazilian semiurban region: an epidemiological study","volume":"20","author":"Siqueira","year":"2016","journal-title":"Rev Bras Neurol Psiq"},{"issue":"suppl 1","key":"2022080602500514400_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/S0074-02762004000900023","article-title":"Factors associated with schistosomiasis mansoni in a population from the municipality of Jaboticatubas, state of Minas Gerais, Brazil","volume":"99","author":"Massara","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"2022080602500514400_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1665-2681(19)32186-6","article-title":"Hepatosplenic schistosomiasis: a model for the study of portal hypertension","volume":"1","author":"Strauss","year":"2002","journal-title":"Ann Hepatol"},{"issue":"4","key":"2022080602500514400_bib23","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3892\/etm.2016.3683","article-title":"Hypersplenism: history and current status","volume":"12","author":"Lv","year":"2016","journal-title":"Exp Ther Med"},{"issue":"2","key":"2022080602500514400_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12264-010-0920-5","article-title":"Research development of the pathogenesis pathways for neuroschistosomiasis","volume":"26","author":"Wang","year":"2010","journal-title":"Neurosci Bull"},{"issue":"suppl 1","key":"2022080602500514400_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0074-02762004000900010","article-title":"Involvement of central nervous system in the schistosomiasis","volume":"99","author":"Ferrari","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"5","key":"2022080602500514400_bib26","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4269\/ajtmh.1989.41.548","article-title":"Histopathological and immunofluorescence study of the choroid plexus in hepatosplenic schistosomiasis mansoni","volume":"41","author":"Pittella","year":"1989","journal-title":"Am J Trop Med Hyg"},{"issue":"1-2","key":"2022080602500514400_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jneuroim.2010.08.016","article-title":"Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis","volume":"230","author":"Ferrari","year":"2011","journal-title":"J Neuroimmunol"},{"issue":"3","key":"2022080602500514400_bib28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies","volume":"88","author":"Fiest","year":"2017","journal-title":"Neurology"},{"issue":"1-3","key":"2022080602500514400_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eplepsyres.2005.07.002","article-title":"Understanding the burden of epilepsy in Latin America: a systematic review of its prevalence and incidence","volume":"66","author":"Burneo","year":"2005","journal-title":"Epilepsy Res"},{"issue":"3B","key":"2022080602500514400_bib30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1590\/S0004-282X2002000500004","article-title":"A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil","volume":"60","author":"Gomes","year":"2002","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"2022080602500514400_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1590\/S0004-282X2002000100014","article-title":"Preval\u00eancia da epilepsia entre os \u00edndios bakairi do estado do Mato Grosso, Brasil","volume":"60","author":"Borges","year":"2001","journal-title":"Arq Neuropsiquiatr"},{"issue":"2a","key":"2022080602500514400_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1590\/S0004-282X2004000200002","article-title":"Urban prevalence of epilepsy. Populational study in S\u00e3o Jos\u00e9 do Rio Preto, a medium-sized city in Brazil","volume":"62","author":"Borges","year":"2004","journal-title":"Arq Neuropsiquiatr"},{"issue":"6","key":"2022080602500514400_bib33","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4269\/ajtmh.2012.11-0419","article-title":"Brain magnetic resonance imaging findings in young patients with hepatosplenic schistosomiasis mansoni without overt symptoms","volume":"86","author":"Manzella","year":"2012","journal-title":"Am J Trop Med Hyg"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/8\/704\/45278148\/trac012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/8\/704\/45278148\/trac012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T02:50:47Z","timestamp":1659754247000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/116\/8\/704\/6532100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,2,18]]},"published-print":{"date-parts":[[2022,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trac012","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"type":"print","value":"0035-9203"},{"type":"electronic","value":"1878-3503"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,2,18]]}}}