{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:34Z","timestamp":1789570954583,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Congenital syphilis (CS) is a problem of great concern for public health, especially in Brazil. The aim of this study was to analyse the time trends and the space\u2013time dynamics of morbidity and mortality from CS in Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An ecological and time series study, which included all cases and deaths from CS recorded in a national Brazilian database from 2013 to 2019 was performed. Time trends in CS incidence and mortality were assessed using segmented linear regression. Univariate global and local Moran indices and space\u2013time scan statistics were used in the space and space\u2013time analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 183\u00a0171 cases and 2401 deaths from CS were recorded in Brazil, with the highest number of cases being observed in the Southeast Region (n=82\u00a0612 [45.1%]). Only 21.1% of pregnant mothers with syphilis received adequate treatment. There was an upward trend in CS rates among mothers ages 20\u201329\u00a0y (average annual percent change [AAPC] 1.4 [95% confidence interval {CI} 1.0 to 1.7]) and with &amp;lt;8\u00a0y of schooling (AAPC 6.6 [95% CI 5.3 to 7.9]). The primary space\u2013time cluster involved 338 municipalities in the Southeast Region (relative risk 3.06, p&amp;lt;0.001) and occurred between 2017 and 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To reduce the trends in CS rates, it is necessary to develop actions to improve the quality of prenatal care and expand early diagnosis and adequate treatment of syphilis in pregnant women and their sexual partners, especially in groups with upward trends (mothers ages 20\u201329\u00a0y and &amp;lt;8\u00a0y of schooling) and living in higher-risk regions (Southeast, North and Northeast).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trac014","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T12:11:23Z","timestamp":1644322283000},"page":"822-831","source":"Crossref","is-referenced-by-count":5,"title":["Space\u2013time risk cluster and time trends of congenital syphilis in Brazil: an ecological study"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-002X","authenticated-orcid":false,"given":"Chaiane Em\u00edlia","family":"Dalazen","sequence":"first","affiliation":[{"name":"Postgraduation in Health and Development of the Midwest Region., Universidade Federal de Mato Grosso do Sul , Campo Grande, Rua Paran\u00e1, n. 174 centro Sidrol\u00e2ndia - Mato Grosso do Sul, 79170-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-672X","authenticated-orcid":false,"given":"Albert Schiaveto","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduation in Health and Development of the Midwest Region., Universidade Federal de Mato Grosso do Sul , Campo Grande, Rua Paran\u00e1, n. 174 centro Sidrol\u00e2ndia - Mato Grosso do Sul, 79170-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-3938","authenticated-orcid":false,"given":"Caique Jordan Nunes","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Nursing Graduate Program, Federal University of Sergipe , S\u00e3o Crist\u00f3v\u00e3o, Sergipe, Rua Maracaj\u00fa, 1136, Ap. 62, Centro, Campo Grande, Mato Grosso do Sul, 79002-212, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-4004","authenticated-orcid":false,"given":"Marquiony","family":"Marques dos Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte , Natal, RN, Rua Professor Dami\u00e3o Teles de Menezes, 15 Condom\u00ednio Arboris, Torre Alfazema, AP 706 Bairro Jabotiana, Sergipe, Aracaju - 49095-806, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4696-0862","authenticated-orcid":false,"given":"Livia Fernandes","family":"Probst","sequence":"additional","affiliation":[{"name":"Unidade de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Hospital Alem\u00e3o Oswaldo Cruz, S\u00e3o Paulo, Laborat\u00f3rio de Inova\u00e7\u00e3o Tecnol\u00f3gica em Sa\u00fade (LAIS\/HUOL\/UFRN) R. do Motor , 282 - Praia do Meio, Natal - RN, 59010-090, Brazil"},{"name":"Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas , Piracicaba, Rua Canxin, 38, Damha 3, Campo Grande, Mato Grosso do Sul, Brazil - 79046-214, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-3280","authenticated-orcid":false,"given":"Melina Raquel","family":"Theobald","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Family Health. Universidade Federal de Mato Grosso do Sul , Campo Grande, Avenida Paulista, 500 5\u00b0 andar - Centro Internacional de Pesquisa 01310-000 Bela vista, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-4524","authenticated-orcid":false,"given":"Alessandro Diogo","family":"De-Carli","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Family Health. 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