{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:00:19Z","timestamp":1789747219583,"version":"4.0.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kyasanur Forest disease (KFD) is a viral zoonotic disease where patients present with febrile illness and haemorrhagic manifestations in the first phase. In a small fraction of patients, the fever may be biphasic. This study aimed to describe the neurological manifestations of patients with KFD in the first and second phases of the illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study of 297 patients admitted with a molecular diagnosis of KFD from December 2018 to December 2020. The case records of these patients were reviewed for evidence of neurological involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 34 (11.5%) patients in the first phase and 16 (36.4%) patients in the second phase had neurological involvement. Altered sensorium, seizures and focal infarcts were common in the first phase, while cerebellar signs and leptomeningeal enhancement were common in the second phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neurological involvement is seen in both phases of KFD. While in the first phase it is a result of possible encephalitis\/encephalopathy, the second phase involvement is possibly due to postinfectious cerebellitis or meningitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trac018","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T16:25:34Z","timestamp":1647275134000},"page":"944-948","source":"Crossref","is-referenced-by-count":16,"title":["Neurological manifestations of Kyasanur Forest disease: a retrospective cohort study from South India"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-2836","authenticated-orcid":false,"given":"Nitin","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"},{"name":"Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu Teja","family":"Nallapati","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"},{"name":"Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-7252","authenticated-orcid":false,"given":"Kiran","family":"Chunduru","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"},{"name":"Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphy Rose James","family":"Vithivattical","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Kadavigere","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-1129","authenticated-orcid":false,"given":"Kavitha","family":"Saravu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"},{"name":"Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education , Manipal 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2022100209504719400_bib1","first-page":"hcaa310","article-title":"Kyasanur Forest disease: state-of-the-art review","author":"Gupta","year":"2020","journal-title":"QJM"},{"issue":"8","key":"2022100209504719400_bib2","first-page":"619","article-title":"Kyasanur Forest disease. III. A preliminary report on the nature of the infection and clinical manifestations in human beings","volume":"11","author":"Work","year":"1957","journal-title":"Indian J Med Sci"},{"issue":"3","key":"2022100209504719400_bib3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0035-9203(61)90067-0","article-title":"Kyasanur Forest disease: a general clinical study in which some cases with neurological complications were observed","volume":"55","author":"Webb","year":"1961","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"2022100209504719400_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0035-9203(66)90296-3","article-title":"Clinical and pathological observations with special reference to the nervous system in Macaca radiata infected with Kyasanur Forest disease virus","volume":"60","author":"Webb","year":"1966","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"2022100209504719400_bib5","first-page":"115","article-title":"Neurological involvement in Kyasanur Forest disease","volume":"23","author":"Wadia","year":"1975","journal-title":"Neurol India"},{"key":"2022100209504719400_bib6","doi-asserted-by":"crossref","first-page":"104735","DOI":"10.1016\/j.jcv.2021.104735","article-title":"Clinical and laboratory profile of patients with Kyasanur Forest disease: a single-centre study of 192 patients from Karnataka, India","volume":"135","author":"Gupta","year":"2021","journal-title":"J Clin Virol"},{"issue":"Supplement_4","key":"2022100209504719400_bib7","doi-asserted-by":"crossref","first-page":"S854","DOI":"10.1093\/clinids\/11.Supplement_4.S854","article-title":"Clinical, clinicopathologic, and hematologic features of Kyasanur Forest disease","volume":"11","author":"Pavri","year":"1989","journal-title":"Rev Infect Dis"},{"issue":"5","key":"2022100209504719400_bib8","first-page":"124","article-title":"Clinical study of 100 cases of Kyasanur Forest disease with clinicopathological correlation","volume":"47","author":"Adhikari Prabha","year":"1993","journal-title":"Indian J Med Sci"},{"issue":"3","key":"2022100209504719400_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/vbz.2017.2129","article-title":"Kyasanur Forest disease prevalence in Western Ghats proven and confirmed by recent outbreak in Maharashtra, India, 2016","volume":"18","author":"Gurav","year":"2018","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"6","key":"2022100209504719400_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jinf.2016.03.006","article-title":"Outbreak of Kyasanur Forest disease (monkey fever) in Sindhudurg, Maharashtra State, India, 2016","volume":"72","author":"Awate","year":"2016","journal-title":"J Infect"},{"issue":"1","key":"2022100209504719400_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ttbdis.2016.09.010","article-title":"An outbreak of Kyasanur Forest disease in the Wayanad and Malappuram districts of Kerala, India","volume":"8","author":"Sadanandane","year":"2017","journal-title":"Ticks Tick-Borne Dis"},{"issue":"5","key":"2022100209504719400_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.12998\/wjcc.v3.i5.430","article-title":"Tick-borne encephalitis: a review of epidemiology, clinical characteristics, and management","volume":"3","author":"Bogovic","year":"2015","journal-title":"World J Clin Cases"},{"issue":"2","key":"2022100209504719400_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/ijmr.IJMR_688_17","article-title":"Clinical & epidemiological significance of Kyasanur Forest disease","volume":"148","author":"Munivenkatappa","year":"2018","journal-title":"Indian J Med Res"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/10\/944\/46287144\/trac018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/116\/10\/944\/46287144\/trac018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T05:59:13Z","timestamp":1664690353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/116\/10\/944\/6556245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":13,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,3,30]]},"published-print":{"date-parts":[[2022,10,2]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trac018","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10]]},"published":{"date-parts":[[2022,3,30]]}}}