{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:51:37Z","timestamp":1791334297602,"version":"4.3.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Soil-transmitted helminths (STH) and schistosome parasites are highly aggregated within the human population. The probability distribution of worms per person is described well by the negative binomial probability distribution with aggregation parameter, k, which varies inversely with parasite clustering. The relationship between k and prevalence in defined populations subject to mass drug administration is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We use statistical methods to estimate k using two large independent datasets for STH and schistosome infections from India and Niger, respectively, both of which demonstrate increased aggregation of parasites in a few hosts, as the prevalence of infections declines across the dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A greater attention needs to be given in monitoring and evaluation programmes to find and treat the remaining aggregates of parasites.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trac033","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T20:11:39Z","timestamp":1648066299000},"page":"1226-1229","source":"Crossref","is-referenced-by-count":13,"title":["The observed relationship between the degree of parasite aggregation and the prevalence of infection within human host populations for soil-transmitted helminth and schistosome infections"],"prefix":"10.1093","volume":"116","author":[{"given":"Klodeta","family":"Kura","sequence":"first","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research , London W2 1PG , UK"},{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London , London W2 1PG , UK"},{"name":"MRC Centre for Global Infectious Disease Analysis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Truscott","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research , London W2 1PG , UK"},{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London , London W2 1PG , UK"},{"name":"MRC Centre for Global Infectious Disease Analysis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin S","family":"Collyer","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research , London W2 1PG , UK"},{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London , London W2 1PG , UK"},{"name":"MRC Centre for Global Infectious Disease Analysis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Phillips","sequence":"additional","affiliation":[{"name":"FHI 360, 1825 Connecticut Avenue NW , Washington DC 20009"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Garba","sequence":"additional","affiliation":[{"name":"World Health Organization , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M","family":"Anderson","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research , London W2 1PG , UK"},{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus, Imperial College London , London W2 1PG , UK"},{"name":"MRC Centre for Global Infectious Disease Analysis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"2022120214244652400_bib1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198545996.001.0001","volume-title":"Infectious Diseases of Humans: Dynamics and Control","author":"Anderson","year":"1991"},{"issue":"(5)","key":"2022120214244652400_bib2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0035-9203(86)90384-6","article-title":"The epidemiology and control of intestinal helminths in the Pulicat Lake region of southern India. 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