{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:52:03Z","timestamp":1772556723242,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Parasitology-Mycology and Tropical Medicine"},{"DOI":"10.13039\/501100010794","name":"Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e9 des Sciences de la Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The level of blood filariasis parasitaemia as well as the frequency of and the relationship between cotrimoxazole prophylaxis (CTX-P), antiretroviral therapy (ART) intake and CD4 cell count among people living with human immunodeficiency virus (PLHIV) in rural areas of Gabon were being studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sociodemographic data and recent biological tests of PLHIV and HIV-negative participants were collected. Loa loa and Mansonella perstans microfilaria were detected by direct microscopy examination and leucoconcentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 209 HIV-positive and 148 HIV-negative subjects were enrolled. The overall prevalence of microfilaria was comparable between PLHIV (19.9% [n=41\/206]) and HIV-negative participants (14.8% [n=22\/148]) (p=0.2). The L. loa infection rate was comparable between HIV-positive (9.2%) and HIV-negative participants (6.8%) (p=0.2), while the M. perstans infection rate was 14-fold higher among PLHIV (p&amp;lt;0.01). L. loa parasitaemia was 6-fold lower in PLHIV receiving CTX-P (median 150\u00a0mf\/mL [interquartile range {IQR} 125\u2013350]) than in patients without (900 [550\u20132225]) (p&amp;lt;0.01). Among subjects with a CD4 cell count &amp;lt;200\u00a0cells\/\u03bcL, the prevalence of M. perstans was 7-fold higher than that of L. loa (20.6% vs 2.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests a similar exposure to L. loa infection of PLHIV and HIV-negative patients while M. perstans is more frequently found in HIV-positive individuals, notably those with a CD4 count &amp;lt;200\u00a0cells\/\u03bcL.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trac034","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:09:33Z","timestamp":1648465773000},"page":"1015-1021","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and risk factors for blood filariasis among HIV-infected adults in Gabon, Central Africa: a pilot study"],"prefix":"10.1093","volume":"116","author":[{"given":"B","family":"Pongui Ngondza","sequence":"first","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9, BP 4009, Libreville , Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"Koumba Lengongo","sequence":"additional","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9, BP 4009, Libreville , Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mickala","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences, Universit\u00e9 des Sciences et Techniques de Masuku , BP 901, Franceville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"M'bondoukw\u00e9","sequence":"additional","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 , BP 4009, Libreville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Ndong Ngomo","sequence":"additional","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 , BP 4009, Libreville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B C","family":"Moutombi Ditombi","sequence":"additional","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 , BP 4009, Libreville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Mawili-Mboumba","sequence":"additional","affiliation":[{"name":"Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 , BP 4009, Libreville, Gabon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M 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