{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:36:58Z","timestamp":1781231818005,"version":"3.54.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) affects approximately 5% of the world\u2019s population, and India has been the second highest country in the numbers of predicted SCD births. Despite the high burden in India, there is no state-led public health programme, and very few interventions dealing with the treatment and management of SCD are available. This review highlights the dearth of SCD-related interventions, and demonstrates that these interventions effectively improve patients' conditions and are feasible to implement in India. We systematically searched three databases\u2014PubMed\/Medline, Google Scholar and Web of Science\u2014for articles from India on SCD-related interventions. The PRISMA guidelines were followed during this review. We included 22 studies, of which 19 dealt with specific therapeutic interventions, and 3 with comprehensive SCD care. Hydroxyurea therapy was the main therapy in 15 studies and is efficacious. Three studies demonstrated the feasibility of comprehensive care in resource-limited settings. The low number of SCD-related intervention studies does not match the huge burden of SCD in India. Governments of endemic countries should consider the findings of available interventions and include them in their countries\u2019 programmes. Comprehensive care is feasible in India and other low-resource settings, from screening to treatment and psychosocial support.<\/jats:p>","DOI":"10.1093\/trstmh\/trac095","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T15:41:54Z","timestamp":1665675714000},"page":"1101-1111","source":"Crossref","is-referenced-by-count":7,"title":["Sickle cell disease treatment and management in India: a systematic review of interventional studies"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-6419","authenticated-orcid":false,"given":"Parikipandla","family":"Sridevi","sequence":"first","affiliation":[{"name":"D , Amarkantak, India"},{"name":"epartment of Biot , Amarkantak, India"},{"name":"echnology, Indira Gandhi National Tribal University , Amarkantak, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-5513","authenticated-orcid":false,"given":"Yogita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Socio-Behavioural & Health Systems Research, Indian Council of Medical Research , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-4440","authenticated-orcid":false,"given":"Sunnam L","family":"Balakrishna","sequence":"additional","affiliation":[{"name":"D , Amarkantak, India"},{"name":"epartment of Biot , Amarkantak, India"},{"name":"echnology, Indira Gandhi National Tribal University , Amarkantak, India"},{"name":"Department of Biochemistry & Molecular Biology, Central University of Kerala , Periye, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-2222","authenticated-orcid":false,"given":"Bontha V","family":"Babu","sequence":"additional","affiliation":[{"name":"Division of Socio-Behavioural & Health Systems Research, Indian Council of Medical Research , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"issue":"2","key":"2022120214251544900_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.hoc.2015.11.005","article-title":"Sickle cell disease in Sub-Saharan Africa","volume":"30","author":"Williams","year":"2016","journal-title":"Hematol Oncol Clin North Am"},{"issue":"9861","key":"2022120214251544900_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates","volume":"381","author":"Piel","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"2022120214251544900_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014699","article-title":"Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania","volume":"6","author":"Makani","year":"2011","journal-title":"PLoS One"},{"key":"2022120214251544900_bib4","volume-title":"Report of the Expert Committee on Tribal Health. 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