{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:55:41Z","timestamp":1780944941458,"version":"3.54.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disseminated neurocysticercosis is defined as simultaneous involvement of the brain (\u22653 cysts) and at least one additional body site\/organ. We aimed to identify disseminated cystic lesions in other body parts and investigate the effect of albendazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients with multiple (\u22653) neurocysticercosis brain lesions. Whole-body MRI (short tau inversion recovery coronal sequences) was performed to assess the number of lesions in the brain and other body parts at baseline and 3 months after albendazole therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 35 patients with multiple brain neurocysticercosis. In 13 patients, whole-body MRI demonstrated disseminated neurocysticercosis lesions. Ten patients were treated with albendazole. We excluded three patients. Brain MRI showed a mean lesion count of 163.6\u00b1193.8. Whole-body MRI (excluding the brain) showed a mean lesion count of 629.9\u00b1486.1. After albendazole therapy, the lesion load of the brain reduced significantly (163.6\u00b1193.8 to 99\u00b1178.3; p=0.008). Similarly, whole-body MRI showed a significant reduction in extracerebral neurocysticercosis lesion load (629.9\u00b1486.1 to 183.4\u00b1301.9; p=0.005). Three patients had complete resolution, five patients showed \u226550% reduction and two patients had &amp;lt;50% reduction in extracerebral lesion load.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Whole-body MRI should routinely be performed in multiple neurocysticercosis lesions of the brain. Albendazole treatment leads to a remarkable reduction in neurocysticercosis lesions throughout the body.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trac097","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T09:06:40Z","timestamp":1666170400000},"page":"271-278","source":"Crossref","is-referenced-by-count":4,"title":["Value of whole-body MRI for the assessment of response to albendazole in disseminated neurocysticercosis: a prospective follow-up study"],"prefix":"10.1093","volume":"117","author":[{"given":"Kinzang","family":"Wangda","sequence":"first","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-4446","authenticated-orcid":false,"given":"Hardeep Singh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Uniyal","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Preet","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences , Lucknow, Uttar Pradesh, 226010 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anit","family":"Parihar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Microbiology, King George's Medical University , Lucknow, Uttar Pradesh, 226003 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"issue":"11","key":"2023040313123813000_","doi-asserted-by":"crossref","first-page":"e0009883","DOI":"10.1371\/journal.pntd.0009883","article-title":"The many facets of disseminated parenchymal brain neurocysticercosis: a differential diagnosis with important therapeutic implications","volume":"15","author":"Del Brutto","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"2023040313123813000_","first-page":"494755221084387","article-title":"Disseminated Neurocysticercosis-should we treat?","author":"George","year":"2022","journal-title":"Trop Doct"},{"issue":"Pt 3","key":"2023040313123813000_","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/brain\/111.3.597","article-title":"Disseminated neurocysticercosis. 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