{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:26:04Z","timestamp":1791656764476,"version":"4.3.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010409","name":"Children's Investment Fund Foundation","doi-asserted-by":"publisher","award":["R-1805-02741"],"award-info":[{"award-number":["R-1805-02741"]}],"id":[{"id":"10.13039\/100010409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive \u2018bounce back\u2019 of STH infection to pretreatment levels post-mass drug administration (MDA). Predisposition is a widespread, but poorly understood phenomena among helminth infections where individuals are predisposed to reinfection after repeated treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This analysis uses Geshiyaro project data, an STH control programme exploring transmission interruption by community-wide MDA and enhanced water, sanitation and hygiene during 2019\u20132023. Parasitological survey data from longitudinal cohorts are analysed using Kendall's Tau-b rank correlation to assess the evidence for predisposition to light or heavy infection between four consecutive rounds of MDA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Correlation analyses revealed the strongest evidence for predisposition to heavy or light Ascaris lumbricoides infection was between survey 1 and 2 (Tau-b 0.29; p&amp;lt;0.001). Overall patterns were not observed for Trichuris trichiura or hookworm infections, however, some significant and notable correlations were recorded for some stratifications and time points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Evidence for predisposition in endemic settings in southern Ethiopia with low STH prevalence suggests that more targeted approaches to MDA in those predisposed to infection may be a sensible control strategy if cheap, point of care diagnostics are available.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trad007","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T13:35:10Z","timestamp":1679319310000},"page":"514-521","source":"Crossref","is-referenced-by-count":14,"title":["Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-9091","authenticated-orcid":false,"given":"Santiago","family":"Rayment Gomez","sequence":"first","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Maddren","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewnetu Firdawek","family":"Liyew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Addis Ababa, Ayat Zone 8, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melkie","family":"Chernet","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Addis Ababa, Ayat Zone 8, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufaysa","family":"Anjulo","sequence":"additional","affiliation":[{"name":"Disease Prevention and Health Promotion Core Process, Ministry of Health , Wolaita, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adugna","family":"Tamiru","sequence":"additional","affiliation":[{"name":"Disease Prevention and Health Promotion Core Process, Ministry of Health , Wolaita, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birhan","family":"Mengitsu","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Forbes","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Collyer","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihretab","family":"Salasibew","sequence":"additional","affiliation":[{"name":"Children's Investment fund Foundation , London W1S 2FT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Anderson","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, St Marys Campus, Imperial College London , London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"issue":"1","key":"2023070411563605300_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-3305-7-37","article-title":"Global numbers of infection and disease burden of soil transmitted helminth infections in 2010","volume":"7","author":"Pullan","year":"2014","journal-title":"Parasit 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