{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:13:57Z","timestamp":1783134837820,"version":"3.54.6"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n, Argentina"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>During the American epidemic, Zika virus (ZIKV) expanded rapidly through dengue virus (DENV)-endemic regions. We analyzed the presentation of ZIKV infection in patients from the City of Or\u00e1n, Argentina, and compared some of its features with dengue presentation in the same region.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective study was conducted at San Vicente de Paul Hospital during 2016\u20132018. Clinical and demographic characteristics, pre-existing immunity to DENV, viral load and type I interferon (IFN) responses were studied in 63 patients with ZIKV infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Clinical manifestations of ZIKV infection were generally mild compared with dengue, although rash (p&amp;lt;0.001) and itching (p&amp;lt;0.001) were significantly more prevalent in ZIKV patients. ZIKV patients aged &amp;lt;15\u00a0y manifested relatively mild disease compared with older ZIKV patients, showing a decreased prevalence of headache (p=0.008), retro-orbital pain (p=0.001) and arthralgia (p=0.001). Increased Zika incidence was observed in female patients (60.3%). Serum viral load was low to undetectable in ZIKV patients and was not associated with serum anti-DENV IgG titers. Interferon-\u03b1 and IFN-\u03b2 serum levels did not correlate with serum viral load in ZIKV patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Clinical presentation of ZIKV and DENV infections is largely overlapping, presenting a challenge for diagnosis and risk assessment for uniquely at-risk populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trad013","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T10:27:36Z","timestamp":1680863256000},"page":"561-568","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiological and clinical features of the 2016\u20132018 Zika virus outbreak in northern Argentina"],"prefix":"10.1093","volume":"117","author":[{"given":"Alana B","family":"Byrne","sequence":"first","affiliation":[{"name":"Labora , Buenos Aires 1425 , Argentina"},{"name":"torio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular, Infectolog\u00eda, Departamento de Medicina, Hospital de Ni\u00f1os Dr Ricardo Guti\u00e9rrez, Gallo 1330 , Buenos Aires 1425 , Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Godoy Cruz 2290, Buenos Aires 1425 , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia A","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Labora , Buenos Aires 1425 , Argentina"},{"name":"torio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular, Infectolog\u00eda, Departamento de Medicina, Hospital de Ni\u00f1os Dr Ricardo Guti\u00e9rrez, Gallo 1330 , Buenos Aires 1425 , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"Bruno","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, Gral. Pizarro S\/N , Or\u00e1n 4530, Salta , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Manuela","family":"Bono","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, Gral. Pizarro S\/N , Or\u00e1n 4530, Salta , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Marta","family":"Contrini","sequence":"additional","affiliation":[{"name":"Labora , Buenos Aires 1425 , Argentina"},{"name":"torio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular, Infectolog\u00eda, Departamento de Medicina, Hospital de Ni\u00f1os Dr Ricardo Guti\u00e9rrez, Gallo 1330 , Buenos Aires 1425 , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Labora , Buenos Aires 1425 , Argentina"},{"name":"torio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular, Infectolog\u00eda, Departamento de Medicina, Hospital de Ni\u00f1os Dr Ricardo Guti\u00e9rrez, Gallo 1330 , Buenos Aires 1425 , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo O","family":"Quipildor","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, Gral. Pizarro S\/N , Or\u00e1n 4530, Salta , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-474X","authenticated-orcid":false,"given":"Laura B","family":"Talarico","sequence":"additional","affiliation":[{"name":"Labora , Buenos Aires 1425 , Argentina"},{"name":"torio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular, Infectolog\u00eda, Departamento de Medicina, Hospital de Ni\u00f1os Dr Ricardo Guti\u00e9rrez, Gallo 1330 , Buenos Aires 1425 , Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Godoy Cruz 2290, Buenos Aires 1425 , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"issue":"3","key":"2023080309050802700_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41579-018-0134-9","article-title":"The evolution of Zika virus from Asia to the Americas","volume":"17","author":"Liu","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"2023080309050802700_bib2","article-title":"The history of Zika virus","author":"World Health Organization"},{"issue":"11-12","key":"2023080309050802700_bib3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.micinf.2018.01.006","article-title":"An overview of mosquito vectors of Zika virus","volume":"20","author":"Boyer","year":"2018","journal-title":"Microbes Infect"},{"key":"2023080309050802700_bib4","article-title":"Cases of Zika Virus Disease: weekly Report","author":"Pan American Health Organization"},{"key":"2023080309050802700_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virol.2020.01.015","article-title":"Zika virus-spread, epidemiology, genome, transmission cycle, clinical manifestation, associated challenges, vaccine and antiviral drug development","volume":"543","author":"Pielnaa","year":"2020","journal-title":"Virology"},{"issue":"1","key":"2023080309050802700_bib6","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1038\/s41598-017-05013-9","article-title":"Asymptomatic transmission and the dynamics of Zika infection","volume":"7","author":"Moghadas","year":"2017","journal-title":"Sci Rep"},{"key":"2023080309050802700_bib7","article-title":"Surveillance of Zika virus","author":"Government of Canada"},{"issue":"4","key":"2023080309050802700_bib8","doi-asserted-by":"crossref","first-page":"ofy073","DOI":"10.1093\/ofid\/ofy073","article-title":"Asymptomatic prenatal Zika virus infection and congenital Zika syndrome","volume":"5","author":"Paixao","year":"2018","journal-title":"Open Forum Infect Dis"},{"issue":"8","key":"2023080309050802700_bib9","doi-asserted-by":"crossref","first-page":"30148","DOI":"10.2807\/1560-7917.ES.2016.21.8.30148","article-title":"An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014","volume":"21","author":"Venturi","year":"2016","journal-title":"Euro Surveill"},{"issue":"5","key":"2023080309050802700_bib10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"2023080309050802700_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1473-3099(19)30547-X","article-title":"Age-dependent manifestations and case definitions of paediatric Zika: a prospective cohort study","volume":"20","author":"Burger-Calderon","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"2023080309050802700_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2471\/BLT.17.201541","article-title":"Prevalence of asymptomatic Zika virus infection: a systematic review","volume":"96","author":"Haby","year":"2018","journal-title":"Bull World Health Organ"},{"issue":"15","key":"2023080309050802700_bib13","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJMra1808246","article-title":"Zika virus infection - 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