{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:06:04Z","timestamp":1776215164373,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2018\/09448-8"],"award-info":[{"award-number":["2018\/09448-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2020\/14783-0"],"award-info":[{"award-number":["2020\/14783-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["#305976\/2022-2"],"award-info":[{"award-number":["#305976\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ocular toxoplasmosis (OT) is a frequent clinical manifestation due to infection by Toxoplasma gondii. It is characterized by an inflammatory process involving macrophages activated by pro-inflammatory cytokines. The expression of microRNAs takes place during the inflammatory process and, among them, miRNA 511 regulates the activation of macrophages. This study evaluated the expression of miRNA 511_5p in patients with OT and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 361 patients from the Hospital de Base of Funda\u00e7\u00e3o Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto were enrolled and divided into four groups: G1\u2013patients with active ocular lesions and reagent serology for T. gondii; G2\u2013patients with scars and reagent serology for T. gondii; G3\u2013patients without ocular lesions or scars and reagent serology for T. gondii; G4\u2013patients without ocular lesions or scars and non-reagent serology for T. gondii. All patients underwent clinical and laboratory evaluation to confirm the diagnosis of OT. Serology tests, RNA extraction and cDNA synthesis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The miRNA 511_5p levels were compared among the groups. The G1 group showed a high blood plasma concentration of miRNA 511_5p (mean 22.34) compared with the G2 (4.65), G3 (8.91) and G4 (3.52) groups (p&amp;lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that miRNA 511_5p has significant potential as a biomarker for OT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trad045","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:52:25Z","timestamp":1688125945000},"page":"804-810","source":"Crossref","is-referenced-by-count":3,"title":["miRNA 511_5p is a potential biomarker for ocular toxoplasmosis"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-1791","authenticated-orcid":false,"given":"Geraldo Magela","family":"de Faria J\u00fanior","sequence":"first","affiliation":[{"name":"Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Avenue, S\u00e3o Jos\u00e9 do Rio Preto, SP, 15090-000, Brazil; Toxoplasma Research Group, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) , S\u00e3o Jos\u00e9 do Rio Preto, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-4094","authenticated-orcid":false,"given":"Laurie Sayuri","family":"Kumano","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Avenue, S\u00e3o Jos\u00e9 do Rio Preto, SP, 15090-000, Brazil; Toxoplasma Research Group, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) , S\u00e3o Jos\u00e9 do Rio Preto, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela","family":"Bronchtein Gomes","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Avenue, S\u00e3o Jos\u00e9 do Rio Preto, SP, 15090-000, Brazil; Toxoplasma Research Group, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) , S\u00e3o Jos\u00e9 do Rio Preto, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-3376","authenticated-orcid":false,"given":"Gl\u00e1ucio Silva","family":"Camargos","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Avenue, S\u00e3o Jos\u00e9 do Rio Preto, SP, 15090-000, Brazil; Toxoplasma Research Group, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) , S\u00e3o Jos\u00e9 do Rio Preto, SP ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-8087","authenticated-orcid":false,"given":"Cristina da Silva","family":"Meira-Strejevitch","sequence":"additional","affiliation":[{"name":"Parasitology and Mycology Center, Adolpho Lutz Institute , 355 Dr Arnaldo Avenue, S\u00e3o Paulo, SP, 01246-000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-2673","authenticated-orcid":false,"given":"Lilian","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), 5416 Brigadeiro Faria Lima Avenue, S\u00e3o Jos\u00e9 do Rio Preto, SP, 15090-000, Brazil; Toxoplasma Research Group, Faculdade de Medicina 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