{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:29:18Z","timestamp":1772155758165,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008816","name":"University of Sri Jayewardenepura","doi-asserted-by":"publisher","award":["ASP\/01\/RE\/MED\/2018\/75"],"award-info":[{"award-number":["ASP\/01\/RE\/MED\/2018\/75"]}],"id":[{"id":"10.13039\/501100008816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Judicious fluid resuscitation and stringent monitoring of clinical parameters improve the outcome of dengue haemorrhagic fever (DHF). The usefulness of serum lactate to monitor adequate fluid therapy has not been adequately explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational study was conducted in Sri Lanka, recruiting 162 DHF patients within 12 h of diagnosis of the critical phase. Venous lactate level was measured at each time of performing haematocrit (HCT), using a prevalidated handheld lactate analyser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median venous lactate level was 1.3 (range 0.3\u20136) mmol\/L in the study population and 154 (95.2%) patients had median lactate levels of &amp;lt;2 mmol\/L. The HCT values in the study participants ranged from 28 to 62, with a median value of 43. There was no statistically significant correlation between the lactate and HCT values obtained at the same time. A significant reduction in venous lactate was not observed following the administration of fluid boluses. The expected reduction in HCT was seen following the administration of dextran and crystalloid\/dextran combination. The maximum recorded lactate level positively correlated with the duration of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study concludes that venous lactate is not an appropriate parameter with which to monitor the response to fluid therapy in uncomplicated DHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trad050","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T19:37:42Z","timestamp":1689795462000},"page":"44-50","source":"Crossref","is-referenced-by-count":0,"title":["A comparison of changes in venous lactate and haematocrit during fluid resuscitation of dengue haemorrhagic fever"],"prefix":"10.1093","volume":"118","author":[{"given":"W D Dilshan","family":"Priyankara","sequence":"first","affiliation":[{"name":"Medical Intensive Care Unit, National Hospital of Sri Lanka , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G N","family":"Samarutilake","sequence":"additional","affiliation":[{"name":"Ministry of Health , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Viswakula","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Colombo , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Manoj","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, National Hospital of Sri Lanka , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Wijewickrama","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases , Angoda , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0154-1864","authenticated-orcid":false,"given":"Nilanka","family":"Perera","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K P","family":"Wanigasuriya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura , Colombo , Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"2024010213083793800_bib1","author":"World Health Organization","year":"2012","journal-title":"Global Strategy for Dengue Prevention and Control, 2012-2020"},{"issue":"8","key":"2024010213083793800_bib2","doi-asserted-by":"crossref","first-page":"taab146","DOI":"10.1093\/jtm\/taab146","article-title":"Global burden for dengue and the evolving pattern in the past 30 years","volume":"28","author":"Yang","year":"2021","journal-title":"J Travel Med"},{"key":"2024010213083793800_bib3","article-title":"Dengue and severe Dengue","author":"World Health Organization"},{"issue":"7446","key":"2024010213083793800_bib4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"2024010213083793800_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijid.2013.10.012","article-title":"Evolution of dengue in Sri Lanka-changes in the virus, vector, and climate","volume":"19","author":"Sirisena","year":"2014","journal-title":"Int J Infect Dis"},{"key":"2024010213083793800_bib6","article-title":"Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever. 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