{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:14:37Z","timestamp":1765728877110,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["16\/136\/29"],"award-info":[{"award-number":["16\/136\/29"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mass drug administration (MDA) is among the five major strategies that are currently in use to control, eliminate or eradicate Neglected Tropical Diseases (NTDs). Optimising MDA to control multiple NTDs maximises impact. The objective of this study is to estimate the secondary impact of ivermectin MDA for onchocerciasis on the prevalence of scabies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This quasi-experimental study was conducted in Ayu Guagusa district, northwestern Ethiopia. Scabies prevalence was estimated in surveys before the MDA, at 6 and 12\u00a0months afterwards. The sample size was 1437 people from a panel of 381 randomly selected study households. Multistage sampling was employed in randomly selecting six kebeles (the lowest administrative unit) with respective gotes (small villages) and households. All members of the selected households were invited to participate in the study and participants who were available in all three surveys formed a cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Scabies prevalence was similar prior to the MDA (13.4%, 95% CI 11.7 to 15.2%) and 6 months after (11.7%, 95% CI 10.1 to 13.2%) but was substantially greater at 12 months (22.1%, 95% CI 20.1 to 24.1%). The 6-month incidence and disappearance rates were 10.8% (95% CI 8.8 to 13.2%) and 82.6% (95% CI 75.0 to 88.6%), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ivermectin MDA for onchocerciasis was not observed to have a secondary impact on the prevalence of scabies over the follow-up period of 12 months.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trad061","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:27:09Z","timestamp":1693852029000},"page":"110-117","source":"Crossref","is-referenced-by-count":1,"title":["No secondary impact of ivermectin mass drug administration for onchocerciasis elimination on the prevalence of scabies in northwestern Ethiopia"],"prefix":"10.1093","volume":"118","author":[{"given":"Robel","family":"Yirgu","sequence":"first","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"School of Public Health, Addis Ababa University , Addis Ababa, 9086 , Ethiopia"},{"name":"Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT)-Africa, Addis Ababa University , Addis Ababa, 9086 , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Middleton","sequence":"additional","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"Department of Primary Care and Public Health, Brighton and Sussex Medical School , Falmer , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abebaw","family":"Fekadu","sequence":"additional","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"Department of Primary Care and Public Health, Brighton and Sussex Medical School , Falmer , UK"},{"name":"Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT)-Africa, Addis Ababa University , Addis Ababa, 9086 , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-7468","authenticated-orcid":false,"given":"Gail","family":"Davey","sequence":"additional","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"School of Public Health, Addis Ababa University , Addis Ababa, 9086 , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bremner","sequence":"additional","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"Department of Primary Care and Public Health, Brighton and Sussex Medical School , Falmer , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Iain","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Brighton and Sussex Medical School , Falmer , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie A","family":"Cassell","sequence":"additional","affiliation":[{"name":"NIHR Global Health Research Unit on Neglected Tropical Diseases, Brighton and Sussex Medical School , Falmer, Brighton BN1 9PX , UK"},{"name":"Department of Primary Care and Public Health, Brighton and Sussex Medical School , Falmer , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"issue":"10066","key":"2024020118321066300_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(16)30171-4","article-title":"Neglected tropical diseases: progress towards addressing the chronic pandemic","volume":"389","author":"Molyneux","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"2024020118321066300_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12936-019-2906-8","article-title":"Mass drug administration can be a valuable addition to the malaria elimination toolbox","volume":"18","author":"Eisele","year":"2019","journal-title":"Malar J"},{"year":"2019","author":"World Health Organization. WHO Informal Consultation on a Framework for Scabies Control. Manila;","key":"2024020118321066300_bib3"},{"issue":"1","key":"2024020118321066300_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijid.2014.03.505","article-title":"Integrating Neglected Tropical Diseases control programs: successes and challenges","volume":"21","author":"Gerba","year":"2014","journal-title":"Int J Infect Dis"},{"issue":"12","key":"2024020118321066300_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.trstmh.2011.08.013","article-title":"Preventive chemotherapy in human helminthiasis: theoretical and operational aspects","volume":"105","author":"Gabrielli","year":"2011","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"16","key":"2024020118321066300_bib6","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1056\/NEJMcp052784","article-title":"Scabies","volume":"354","author":"Chosidow","year":"2006","journal-title":"N Engl J Med"},{"issue":"8","key":"2024020118321066300_bib7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S1473-3099(15)00132-2","article-title":"Prevalence of scabies and impetigo worldwide: A systematic review","volume":"15","author":"Romani","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"2024020118321066300_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0005726","article-title":"Are scabies and impetigo \u2018normalised\u2019? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections","volume":"11","author":"Yeoh","year":"2017","journal-title":"PLOS Negl Trop Dis"},{"issue":"5","key":"2024020118321066300_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1473-3099(18)30790-4","article-title":"Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: A single-arm community intervention trial","volume":"19","author":"Romani","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"2024020118321066300_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/QCO.0b013e3283511d27","article-title":"Streptococcal skin infection and rheumatic heart disease","volume":"25","author":"Parks","year":"2012","journal-title":"Curr Opin Infect Dis"},{"issue":"24","key":"2024020118321066300_bib11","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1500987","article-title":"Mass drug administration for scabies control in a population with endemic disease","volume":"373","author":"Romani","year":"2015","journal-title":"N Engl J Med"},{"issue":"6","key":"2024020118321066300_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/ijd.12353","article-title":"Scabies community prevalence and mass drug administration in two Fijian villages","volume":"53","author":"Haar","year":"2014","journal-title":"Int J Dermatol"},{"issue":"10","key":"2024020118321066300_bib13","doi-asserted-by":"crossref","first-page":"e1132","DOI":"10.1016\/S2214-109X(18)30397-8","article-title":"Feasibility and safety of mass drug coadministration with azithromycin and ivermectin for the control of neglected tropical diseases: A single-arm intervention trial","volume":"6","author":"Romani","year":"2018","journal-title":"The Lancet Global Health"},{"issue":"12","key":"2024020118321066300_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004246","article-title":"Long term control of scabies fifteen years after an intensive treatment programme","volume":"9","author":"Marks","year":"2015","journal-title":"PLOS Negl Trop Dis"},{"article-title":"Ending the neglect to attend the sustainable development goals: A road map for neglected tropical diseases 2021\u20132030. Geneva","year":"2020","author":"World Health Organization","key":"2024020118321066300_bib15"},{"issue":"6","key":"2024020118321066300_bib16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/cid\/ciy574","article-title":"Randomized trial of community treatment with azithromycin and ivermectin mass drug administration for control of scabies and impetigo","volume":"68","author":"Marks","year":"2019","journal-title":"Clin Infect Dis."},{"issue":"299","key":"2024020118321066300_bib17","first-page":"1","article-title":"Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis: A rapid assessment methodology to assess impact","volume":"5","author":"Mohammed","year":"2012","journal-title":"BioMed Central"},{"year":"2008","key":"2024020118321066300_bib18","article-title":"Federal Democratic Republic of Ethiopia Population Census Commission. Summary and statistical report of the 2007 population and housing census"},{"issue":"1","key":"2024020118321066300_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12992-019-0470-1","article-title":"Community health extension program of Ethiopia, 2003\u20132018: Successes and challenges toward universal coverage for primary healthcare services","volume":"15","author":"Assefa","year":"2019","journal-title":"Global Health"},{"issue":"114","key":"2024020118321066300_bib20","first-page":"1","article-title":"Investigation of a scabies outbreak in drought-affected areas in Ethiopia","volume":"3","author":"Enbiale","year":"2018","journal-title":"Trop Med Infect Dis"},{"issue":"06.1","key":"2024020118321066300_bib21","doi-asserted-by":"crossref","first-page":"78s","DOI":"10.3855\/jidc.11892","article-title":"Does mass drug administration for community-based scabies control works? The experience in Ethiopia","volume":"14","author":"Enbiale","year":"2020","journal-title":"J Infect Dev Ctries"},{"issue":"06.1","key":"2024020118321066300_bib22","doi-asserted-by":"crossref","first-page":"28S","DOI":"10.3855\/jidc.11701","article-title":"Stopping the itch\u2019: Mass drug administration for scabies outbreak control covered for over nine million people in Ethiopia","volume":"14","author":"Enbiale","year":"2020","journal-title":"J Infect Dev Ctries"},{"issue":"1","key":"2024020118321066300_bib23","first-page":"55","article-title":"Review of Ethiopian Onchocerciasis Elimination Programme","volume":"55","author":"Meribo","year":"2017","journal-title":"Ethiop Med J"},{"volume-title":"Federal Democratic Republic of Ethiopia Ministry of Health. Second Edition of National Neglected Tropical Diseases Master Plan","year":"2016","key":"2024020118321066300_bib24"},{"volume-title":"Federal Democratic Republic of Ethiopia Ministry of Health. Guidelines for onchcerciasis elimination in Ethiopia","year":"2015","key":"2024020118321066300_bib25"},{"issue":"10","key":"2024020118321066300_bib26","doi-asserted-by":"crossref","first-page":"e0004151","DOI":"10.1371\/journal.pntd.0004151","article-title":"Impact of an ivermectin mass drug administration on scabies prevalence in a remote Australian aboriginal community","volume":"9","author":"Kearns","year":"2015","journal-title":"PLOS Negl Trop Dis"},{"issue":"1","key":"2024020118321066300_bib27","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/S2214-109X(19)30453-X","article-title":"Safety of oral ivermectin during pregnancy: A systematic review and meta-analysis","volume":"8","author":"Nicolas","year":"2020","journal-title":"Lancet Global Health"},{"year":"2023","author":"Yirgu","key":"2024020118321066300_bib28"},{"issue":"4","key":"2024020118321066300_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/cc1521","article-title":"Statistics review 4: Sample size calculations","volume":"2","author":"Whitley","year":"2002","journal-title":"Crit Care"},{"key":"2024020118321066300_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijid.2022.10.043","article-title":"Effects of ivermectin mass drug administration for malaria vector control on ectoparasites and soil-transmitted helminths: A cluster randomized trial","volume":"125","author":"Kositz","year":"2022","journal-title":"Int J Infect Dis"},{"issue":"1","key":"2024020118321066300_bib31","first-page":"34","article-title":"Control of scabies, skin sores and haematuria in children in the Solomon Islands: Another role for ivermectin","volume":"83","author":"Lawrence","year":"2005","journal-title":"Bull World Health Organ"},{"issue":"8","key":"2024020118321066300_bib32","doi-asserted-by":"crossref","first-page":"e037305","DOI":"10.1136\/bmjopen-2020-037305","article-title":"Protocol for a cluster-randomised non-inferiority trial of one versus two doses of ivermectin for the control of scabies using a mass drug administration strategy (the RISE study)","volume":"10","author":"Lake","year":"2020","journal-title":"BMJ Open"},{"issue":"8748","key":"2024020118321066300_bib33","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/0140-6736(91)92669-S","article-title":"Community control of scabies: A model based on use of permethrin cream","volume":"337","author":"Taplin","year":"1991","journal-title":"Lancet"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/118\/2\/110\/56535229\/trad061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/118\/2\/110\/56535229\/trad061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T19:17:34Z","timestamp":1706815054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/118\/2\/110\/7259717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2024,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trad061","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"type":"print","value":"0035-9203"},{"type":"electronic","value":"1878-3503"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2023,9,4]]}}}