{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:51:45Z","timestamp":1793235105366,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To provide a continuous update on the safety and efficacy of artesunate-mefloquine (ASMQ) compared with other artemisinin combination therapy (ACT) schemes used in the treatment of uncomplicated malaria caused by Plasmodium falciparum, this study updated and expanded the results of the systematic literature review published in 2016. Only randomised controlled clinical trials published from 1 January 2001 to 12 June 2023 from five databases were included in this study. The results related to efficacy, expressed through RR, were summarized in meta-analyses, performed according to the compared ACTs and with the intention-to-treat and per-protocol analyses. The results related to safety were synthesized in a descriptive manner. Thirty-two studies were included, of which 24 had been analysed in the 2016 review and eight new ones were added. Although the methodological quality of most studies was considered moderate, the body of evidence gathered indicates that ASMQ continues to be safe and effective for the treatment of uncomplicated infections caused by P. falciparum compared with other ACTs. However, the inclusion of two new studies, which identified failure rates exceeding 10%, suggests a possible reduction in the efficacy of ASMQ in the analysed locations. The incidence of serious adverse effects, such as seizure, encephalopathy and cardiac arrhythmia, was infrequent in both the ASMQ group and the comparison groups. After including new evidence, ASMQ is still recommended as a first-line treatment of uncomplicated malaria caused by P. falciparum, although local aspects need to be considered.<\/jats:p>","DOI":"10.1093\/trstmh\/trad069","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:13:28Z","timestamp":1695993208000},"page":"84-94","source":"Crossref","is-referenced-by-count":4,"title":["Artesunate-mefloquine therapy for uncomplicated <i>Plasmodium falciparum<\/i> malaria: an updated systematic review and meta-analysis of efficacy and safety"],"prefix":"10.1093","volume":"118","author":[{"given":"Beatriz Sales","family":"de Freitas","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Brasilia (UnB), Brasilia, University Campus Darcy Ribeiro , Asa Norte, Bras\u00edlia, DF 70910-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Haiek","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Brasilia (UnB), Brasilia, University Campus Darcy Ribeiro , Asa Norte, Bras\u00edlia, DF 70910-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-844X","authenticated-orcid":false,"given":"Ana Carolina Esteves da Silva","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine, University of Bras\u00edlia (UnB), University Campus Darcy Ribeiro , Asa Norte, Bras\u00edlia, DF 70904970 \u00a0 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5982-8855","authenticated-orcid":false,"given":"Henry Maia","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Brasilia (UnB), Brasilia, University Campus Darcy Ribeiro , Asa Norte, Bras\u00edlia, DF 70910-900 , Brazil"},{"name":"Centre for Tropical Medicine, University of Bras\u00edlia (UnB), University Campus Darcy Ribeiro , Asa Norte, Bras\u00edlia, DF 70904970 \u00a0 Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment (IATS\/CNPq) , Porto Alegre, Rio Grande do Sul 90035-903 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"2024020118321638900_bib1","first-page":"238","author":"World Health Organization","year":"2022;"},{"key":"2024020118321638900_bib2","author":"World Health Organization","year":"2022"},{"key":"2024020118321638900_bib3","volume-title":"Malaria - Malaria Worldwide - Impact of Malaria","author":"CDC","year":"2021"},{"key":"2024020118321638900_bib4","doi-asserted-by":"crossref","first-page":"205031212210880","DOI":"10.1177\/20503121221088085","article-title":"Prevalence of asymptomatic malaria and associated factors in Ethiopia: systematic review and meta-analysis","volume":"10","author":"Tamiru","year":"2022","journal-title":"SAGE Open Med"},{"key":"2024020118321638900_bib5","volume-title":"Global Technical Strategy for Malaria 2016-2030, 2021 Update [Internet]","author":"World Health Organization","year":"2021"},{"issue":"1","key":"2024020118321638900_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-022-04151-4","article-title":"The primate malaria parasites plasmodium malariae, plasmodium brasilianum and plasmodium ovale spp.: genomic insights into distribution, dispersal and host transitions","volume":"21","author":"Fuehrer","year":"2022","journal-title":"Malar J"},{"issue":"5","key":"2024020118321638900_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2022.12366","article-title":"Diagnosis, treatment, and prevention of malaria in the US: a review","volume":"328","author":"Daily","year":"2022","journal-title":"JAMA"},{"key":"2024020118321638900_bib8","first-page":"33","article-title":"Revised WHO treatment recommendations for malaria","volume-title":"WHO Drug Inf","author":"World Health Organization","year":"2006"},{"key":"2024020118321638900_bib9","year":"2021"},{"issue":"2","key":"2024020118321638900_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00003088-200847020-00002","article-title":"Clinical pharmacology of artemisinin-based combination therapies","volume":"47","author":"German","year":"2008","journal-title":"Clin Pharmacokinet"},{"key":"2024020118321638900_bib11","first-page":"1","article-title":"Efficacy and safety of Artemisinin-Piperaquine for the treatment of uncomplicated malaria: a systematic review","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharmacol"},{"issue":"5","key":"2024020118321638900_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4269\/ajtmh.2002.67.465","article-title":"Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute plasmodium falciparum malaria: randomized, double-blind study in Thailand","volume":"67","author":"Krudsood","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"2024020118321638900_bib13","doi-asserted-by":"crossref","first-page":"104275","DOI":"10.1016\/j.phrs.2019.104275","article-title":"Development of artemisinin resistance in malaria therapy","volume":"146","author":"Na\u00df","year":"2019","journal-title":"Pharmacol Res"},{"issue":"11","key":"2024020118321638900_bib14","first-page":"626","article-title":"Efficacy and safety of artesunate-mefloquine therapy for treating uncomplicated Plasmodium falciparum malaria: systematic review and meta-analysis","volume":"110","author":"Peixoto","year":"2016","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"2024020118321638900_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.17843\/rpmesp.2018.353.3891","article-title":"Impacto de diferentes esquemas terap\u00e9uticos sobre la malaria en la costa y amazonia peruana, en el marco de una pol\u00edtica de medicamentos antimal\u00e1ricos, 1994-2017","volume":"35","author":"Durand","year":"2018","journal-title":"Rev peru med exp salud publica"},{"issue":"1","key":"2024020118321638900_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12936-022-04279-3","article-title":"Efficacy of three anti-malarial regimens for uncomplicated plasmodium falciparum malaria in Cambodia, 2009-2011: a randomized controlled trial and brief review","volume":"21","author":"Lek","year":"2022","journal-title":"Malar J"},{"issue":"1","key":"2024020118321638900_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-017-1925-6","article-title":"Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination","volume":"16","author":"Recht","year":"2017","journal-title":"Malar J"},{"key":"2024020118321638900_bib18","article-title":"Strategy to respond to antimalarial drug resistance in Africa [Internet]","author":"World Health Organization","year":"2022"},{"issue":"2","key":"2024020118321638900_bib19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/bcp.14474","article-title":"Advances and roadblocks in the treatment of malaria","volume":"88","author":"Hanboonkunupakarn","year":"2022","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"2024020118321638900_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-018-1156-x","article-title":"High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure","volume":"16","author":"Tyagi","year":"2018","journal-title":"BMC Med"},{"issue":"4","key":"2024020118321638900_bib21","first-page":"11","article-title":"Artesunate resistance - an emerging threat","volume":"70","author":"Nair","year":"2022","journal-title":"J Assoc Physicians India"},{"key":"2024020118321638900_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/5539544","article-title":"Efforts made to eliminate drug-resistant malaria and its challenges","volume":"2021","author":"Amelo","year":"2021","journal-title":"Biomed Res Int"},{"key":"2024020118321638900_bib23","doi-asserted-by":"crossref","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"issue":"1","key":"2024020118321638900_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01500-16","article-title":"Critical evaluation of molecular monitoring in Malaria drug efficacy trials and pitfalls of length-polymorphic markers","volume":"61","author":"Messerli","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2024020118321638900_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1475-2875-6-80","article-title":"Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated plasmodium falciparum malaria in Senegal","volume":"6","author":"Faye","year":"2007","journal-title":"Malar J"},{"issue":"1","key":"2024020118321638900_bib26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4269\/ajtmh.2010.09-0265","article-title":"A randomized trial of artesunate mefloquine versus artemether lumefantrine for the treatment of uncomplicated plasmodium falciparum malaria in Senegalese children","volume":"82","author":"Faye","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2024020118321638900_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-3156.2010.02701.x","article-title":"Artesunate\/mefloquine paediatric formulation vs. artemether\/lumefantrine for the treatment of uncomplicated plasmodium falciparum in Anonkoua kout\u00e9, C\u00f4te d'Ivoire","volume":"16","author":"Toure","year":"2011","journal-title":"Trop Med Int Health"},{"issue":"10","key":"2024020118321638900_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.trstmh.2005.02.007","article-title":"Efficacy of chloroquine + sulfadoxine\u2013pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh","volume":"99","author":"van den Broek I","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"2024020118321638900_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4269\/ajtmh.2012.11-0192","article-title":"Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria","volume":"86","author":"Carrasquilla","year":"2012","journal-title":"Am J Trop Med Hyg"},{"issue":"10","key":"2024020118321638900_bib30","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1086\/425015","article-title":"Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand","volume":"190","author":"Ashley","year":"2004","journal-title":"J Infect Dis"},{"issue":"4","key":"2024020118321638900_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/432011","article-title":"A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria","volume":"41","author":"Ashley","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"10","key":"2024020118321638900_bib32","doi-asserted-by":"crossref","first-page":"e1101","DOI":"10.1371\/journal.pone.0001101","article-title":"A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru","volume":"2","author":"Grande","year":"2007","journal-title":"PLoS One"},{"issue":"2","key":"2024020118321638900_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-3156.2006.01786.x","article-title":"A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia","volume":"12","author":"Janssens","year":"2007","journal-title":"Trop Med Int Health"},{"issue":"8","key":"2024020118321638900_bib34","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-3156.2006.01671.x","article-title":"An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)","volume":"11","author":"Mayxay","year":"2006","journal-title":"Trop Med Int Health"},{"issue":"6","key":"2024020118321638900_bib35","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4269\/ajtmh.2010.10-0276","article-title":"A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated plasmodium falciparum malaria in southern Laos","volume":"83","author":"Mayxay","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"9528","key":"2024020118321638900_bib36","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0140-6736(06)68931-9","article-title":"Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison","volume":"367","author":"Smithuis","year":"2006","journal-title":"Lancet"},{"issue":"1","key":"2024020118321638900_bib37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1475-2875-4-46","article-title":"A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant plasmodium falciparum on the western border of Thailand","volume":"4","author":"Hutagalung","year":"2005","journal-title":"Malar J"},{"issue":"5","key":"2024020118321638900_bib38","first-page":"1085","article-title":"An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria","volume":"36","author":"Tangpukdee","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"9402","key":"2024020118321638900_bib39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(03)15163-X","article-title":"Dihydroartemisinin-piperaquine against multidrug-resistant plasmodium falciparum malaria in Vietnam: randomised clinical trial","volume":"363","author":"Tran","year":"2004","journal-title":"Lancet"},{"issue":"7","key":"2024020118321638900_bib40","doi-asserted-by":"crossref","first-page":"e11880","DOI":"10.1371\/journal.pone.0011880","article-title":"An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia","volume":"5","author":"Valecha","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"2024020118321638900_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1475-2875-11-233","article-title":"Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India","volume":"11","author":"Gargano","year":"2012","journal-title":"Malar J"},{"issue":"5\u20136","key":"2024020118321638900_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4269\/ajtmh.2001.64.247","article-title":"A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant plasmodium falciparum malaria in Thailand","volume":"64","author":"Lef\u00e8vre","year":"2001","journal-title":"Am J Trop Med Hyg"},{"issue":"8","key":"2024020118321638900_bib43","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1086\/424512","article-title":"Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic","volume":"39","author":"Mayxay","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2024020118321638900_bib44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4269\/ajtmh.2008.79.655","article-title":"A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for treatment of uncomplicated plasmodium falciparum malaria in Mali","volume":"79","author":"Sagara","year":"2008","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"2024020118321638900_bib45","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1128\/AAC.05388-11","article-title":"Comparative efficacies of artemisinin combination therapies in Plasmodium falciparum malaria and polymorphism of pfATPase6, pfcrt, pfdhfr, and pfdhps genes in tea gardens of Jalpaiguri District, India","volume":"56","author":"Saha","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"2024020118321638900_bib46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1473-3099(10)70187-0","article-title":"Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial","volume":"10","author":"Smithuis","year":"2010","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"2024020118321638900_bib47","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-3156.2004.01320.x","article-title":"Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated plasmodium falciparum malaria in Luang Namtha Province, Lao People's Democratic Republic","volume":"9","author":"Stohrer","year":"2004","journal-title":"Trop Med Int Health"},{"issue":"1","key":"2024020118321638900_bib48","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1186\/1475-2875-11-416","article-title":"Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial","volume":"11","author":"Tine","year":"2012","journal-title":"Malar J"},{"issue":"10","key":"2024020118321638900_bib49","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S1473-3099(16)30020-2","article-title":"Comparison of artesunate-mefloquine and artemether-lumefantrine fixed-dose combinations for treatment of uncomplicated plasmodium falciparum malaria in children younger than 5 years in sub-Saharan Africa: a randomised, multicentre, phase 4 trial","volume":"16","author":"Sirima","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"10233","key":"2024020118321638900_bib50","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(20)30552-3","article-title":"Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial","volume":"395","author":"van der Pluijm","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"2024020118321638900_bib51","first-page":"519","article-title":"An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand","volume":"33","author":"Wilairatana","year":"2002","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"1","key":"2024020118321638900_bib52","first-page":"1","article-title":"Efficacy of Artequick versus artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand","volume":"39","author":"Tangpukdee","year":"2008","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"6","key":"2024020118321638900_bib53","first-page":"971","article-title":"Dose ranging studies of new artemisinin-piperaquine fixed combinations compared to standard regimens of artemisisnin combination therapies for acute uncomplicated falciparum malaria","volume":"38","author":"Krudsood","year":"2007","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"12","key":"2024020118321638900_bib54","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1086\/344901","article-title":"Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil","volume":"35","author":"van Vugt","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"14","key":"2024020118321638900_bib55","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1056\/NEJMoa1007125","article-title":"Pyronaridine-artesunate versus mefloquine plus artesunate for malaria","volume":"366","author":"Rueangweerayut","year":"2012","journal-title":"N Engl J Med"},{"issue":"10","key":"2024020118321638900_bib56","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1473-3099(10)70187-0","article-title":"Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial","volume":"10","author":"Smithuis","year":"2010","journal-title":"Lancet Infect Dis"},{"issue":"9528","key":"2024020118321638900_bib57","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0140-6736(06)68931-9","article-title":"Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison","volume":"367","author":"Smithuis","year":"2006","journal-title":"Lancet"},{"issue":"3","key":"2024020118321638900_bib58","first-page":"CD007483","article-title":"Artemisinin-based combination therapy for treating uncomplicated malaria","volume":"2009","author":"Sinclair","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"2024020118321638900_bib59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tmaid.2008.12.004","article-title":"Mefloquine neurotoxicity: a literature review","volume":"7","author":"Toovey","year":"2009","journal-title":"Travel Med Infect Dis"},{"issue":"1","key":"2024020118321638900_bib60","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/1475-2875-12-385","article-title":"Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review","volume":"12","author":"Egunsola","year":"2013","journal-title":"Malar J"},{"issue":"2","key":"2024020118321638900_bib61","doi-asserted-by":"crossref","first-page":"e0168780","DOI":"10.1371\/journal.pone.0168780","article-title":"Adverse effects of mefloquine for the treatment of uncomplicated malaria in Thailand: a pooled analysis of 19, 850 individual patients","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"2024020118321638900_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/infdis\/jiv093","article-title":"A randomized trial to compare the safety, tolerability, and effectiveness of 3 antimalarial regimens for the prevention of malaria in Nigerian patients with Sickle cell disease","volume":"212","author":"Olaosebikan","year":"2015","journal-title":"J Infect Dis"},{"key":"2024020118321638900_bib63","doi-asserted-by":"crossref","first-page":"876282","DOI":"10.3389\/fphar.2022.876282","article-title":"Artemisinin resistance and malaria elimination: where are we now?","volume":"13","author":"Hanboonkunupakarn","year":"2022","journal-title":"Front Pharmacol"},{"issue":"4","key":"2024020118321638900_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.00019-19","article-title":"Plasmodium Genomics and genetics: new insights into malaria pathogenesis, drug resistance, epidemiology, and evolution","volume":"32","author":"Su","year":"2019","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"2024020118321638900_bib65","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrmicro.2017.161","article-title":"Drug resistance in Plasmodium","volume":"16","author":"Haldar","year":"2018","journal-title":"Nat Rev Microbiol"}],"container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/118\/2\/84\/56535233\/trad069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/118\/2\/84\/56535233\/trad069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T19:18:16Z","timestamp":1706815096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/118\/2\/84\/7286242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,29]]},"published-print":{"date-parts":[[2024,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trad069","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2023,9,29]]}}}