{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:17:40Z","timestamp":1793143060299,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88882.306447\/2018-01"],"award-info":[{"award-number":["88882.306447\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88881.505364\/2020-01"],"award-info":[{"award-number":["88881.505364\/2020-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88881.507066\/2020-01"],"award-info":[{"award-number":["88881.507066\/2020-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["310974\/2020-8"],"award-info":[{"award-number":["310974\/2020-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The clinical picture of coronavirus disease 2019 (COVID-19)-associated sepsis is similar to that of sepsis of other aetiologies. The present study aims to analyse the role of syndecan-1 (SDC-1) as a potential predictor of septic shock in critically ill patients with COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a prospective study of 86 critically ill patients due to COVID-19 infection. Patients were followed until day 28 of hospitalization. Vascular biomarkers, such as vascular cell adhesion protein-1, SDC-1, angiopoietin-1 and angiopoietin-2, were quantified upon admission and associated with the need for vasopressors in the first 7\u00a0d of hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 86 patients with COVID-19 (mean age 60\u00b116\u00a0y; 51 men [59%]) were evaluated. Thirty-six (42%) patients died during hospitalization and 50 (58%) survived. The group receiving vasopressors had higher levels of D-dimer (2.46\u00a0ng\/ml [interquartile range {IQR} 0.6\u20136.1] vs 1.01\u00a0ng\/ml [IQR 0.62\u20132.6], p=0.019) and lactate dehydrogenase (929\u00b1382\u00a0U\/l vs 766\u00b1312\u00a0U\/l, p=0.048). The frequency of deaths during hospitalization was higher in the group that received vasoactive amines in the first 24\u00a0h in the intensive care unit (70% vs 30%, p=0.002). SDC-1 levels were independently associated with the need for vasoactive amines, and admission values &amp;gt;269\u00a0ng\/ml (95% CI 0.524 to 0.758, p=0.024) were able to predict the need for vasopressors during the 7\u00a0d following admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Syndecan-1 levels predict septic shock in critically ill patients with COVID-19.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trad077","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T10:04:36Z","timestamp":1698487476000},"page":"160-169","source":"Crossref","is-referenced-by-count":6,"title":["Syndecan-1 levels predict septic shock in critically ill patients with COVID-19"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-9369","authenticated-orcid":false,"given":"Nilcyeli Linhares","family":"Arag\u00e3o","sequence":"first","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. Fortaleza , Cear\u00e1 , Brazil"},{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-0475","authenticated-orcid":false,"given":"Marza de Sousa","family":"Zaranza","sequence":"additional","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. Fortaleza , Cear\u00e1 , Brazil"},{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-5728","authenticated-orcid":false,"given":"Gdayllon Cavalcante","family":"Meneses","sequence":"additional","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. Fortaleza , Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-4030","authenticated-orcid":false,"given":"Ana Paula Pires","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Public Health Postgraduate Program, School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza , Cear\u00e1 , Brazil"},{"name":"School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza , Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-5130","authenticated-orcid":false,"given":"\u00c1lvaro Rolim","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. Fortaleza , Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8160-2027","authenticated-orcid":false,"given":"Alice Maria Costa","family":"Martins","sequence":"additional","affiliation":[{"name":"Clinical and Toxicological Analysis Department, School of Pharmacy, Universidade Federal do Cear\u00e1 , Fortaleza , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-6144","authenticated-orcid":false,"given":"Natalia Linhares Ponte","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-864X","authenticated-orcid":false,"given":"Andrea Mazza","family":"Beliero","sequence":"additional","affiliation":[{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-0994","authenticated-orcid":false,"given":"Geraldo Bezerra","family":"da Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Public Health Postgraduate Program, School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza , Cear\u00e1 , Brazil"},{"name":"School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza , Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-1610","authenticated-orcid":false,"given":"Sandra Mara Brasileiro","family":"Mota","sequence":"additional","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. Fortaleza , Cear\u00e1 , Brazil"},{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-1711","authenticated-orcid":false,"given":"Polianna Lemos Moura Moreira","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"School of Medicine, Health Sciences Center, Universidade de Fortaleza, Fortaleza , Cear\u00e1 , Brazil"},{"name":"Instituto Jos\u00e9 Frota Hospital , Fortaleza, Cear\u00e1 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-1738","authenticated-orcid":false,"given":"Elizabeth De Francesco","family":"Daher","sequence":"additional","affiliation":[{"name":"Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Universidade Federal do Cear\u00e1. 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