{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:39:44Z","timestamp":1793295584264,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007225","name":"Vietnamese Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NDT.82.GB\/20"],"award-info":[{"award-number":["NDT.82.GB\/20"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research","award":["01DP13007"],"award-info":[{"award-number":["01DP13007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The epidemiology of melioidosis in Vietnam, a disease caused by the soil bacterium Burkholderia pseudomallei, remains unclear. This study aimed to detect paediatric melioidosis in South Vietnam and describe clinical features and the geographic distribution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We introduced a simple laboratory algorithm for detecting B. pseudomallei from clinical samples at Children's Hospital 2 in Ho Chi Minh City in July 2015. A retrospective observational study of children &amp;lt;16\u00a0y of age with culture-confirmed melioidosis between July 2015 and August 2019 was undertaken.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-five paediatric cases of melioidosis were detected, with cases originating from 13 of 32 provinces and cities in South Vietnam. The number of paediatric melioidosis cases detected from a certain region correlated with the overall number of inpatients originating from the respective geographic area. Suppurative parotitis (n=15 [42.8%]) was the most common clinical presentation, followed by lung infection (n=10 [28.6%]) and septicaemia (n=7 [20%]). Fourteen (40%) children had disseminated disease, including all cases of lung infection, four cases with central nervous system symptoms and four (11.4%) deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The patients\u2019 origin indicates a wide distribution of melioidosis in South Vietnam. It seems probable that cases not only in children, but also in adults, remain grossly undiagnosed. Further awareness raising and laboratory capacity strengthening are needed in this part of the country.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trad080","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T21:50:41Z","timestamp":1700862641000},"page":"190-198","source":"Crossref","is-referenced-by-count":7,"title":["Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-1384","authenticated-orcid":false,"given":"Thai Son","family":"Pham","sequence":"first","affiliation":[{"name":"Children's Hospital 2 , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The Trung","family":"Bui","sequence":"additional","affiliation":[{"name":"Children's Hospital 2 , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Ngoc Anh","family":"Vu","sequence":"additional","affiliation":[{"name":"VNU Institute of Microbiology and Biotechnology, Vietnam National University , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Nam","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Children's Hospital 2 , Ho Chi Minh City , Vietnam"},{"name":"City Children's Hospital , Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau Viet","family":"Do","sequence":"additional","affiliation":[{"name":"Children's Hospital 2 , Ho Chi Minh City , 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