{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:49:33Z","timestamp":1785797373221,"version":"3.56.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2021-HGDKG"],"award-info":[{"award-number":["2021-HGDKG"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2022-1DNS6"],"award-info":[{"award-number":["2022-1DNS6"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302675\/2019-1"],"award-info":[{"award-number":["302675\/2019-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Control interventions recommended by the World Health Organization have successfully resulted in low-intensity schistosomiasis transmission areas. To achieve elimination of transmission, new diagnostic screening tools are needed to overcome less than adequate sensitivity of the currently used Kato\u2013Katz faecal thick smear method. Ideally, in-house serological tests should be avoided due to not having a continuous supply of kits as would be necessary for large population studies. Quality assurance provided by manufacturers and proper performance evaluations are also needed. We evaluated the accuracy of two commercially available serology tests as screening methods for detecting light schistosomiasis infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum samples were collected in 2015 from individuals living in a low-endemicity locality in northeastern Brazil and deposited in a biorepository. We evaluated immunoglobulin G (IgG) and IgM enzyme-linked immunosorbent assays (ELISAs) and an immunochromatographic test (ICT). The Helmintex method was used to define true-positive samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall sensitivity was close to 90% for both the IgG ELISA and ICT, yet specificity was 28% and 18%, respectively. For the IgM ELISA, the values were estimated to be 55% and 43%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Poor specificity and positive predictive values prevent these tests from being recommended for screening populations in low-intensity schistosomiasis-endemic areas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trae005","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T16:30:42Z","timestamp":1708792242000},"page":"514-519","source":"Crossref","is-referenced-by-count":2,"title":["Accuracy of commercial ELISA and ICT for screening schistosomiasis infections at a low endemicity area in Brazil"],"prefix":"10.1093","volume":"118","author":[{"given":"Lida M S","family":"Ramos","sequence":"first","affiliation":[{"name":"N\u00facleo de Doen\u00e7as Infecciosas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Esp\u00edrito Santo , Vit\u00f3ria 29043-910 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S C A","family":"Pereira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Doen\u00e7as Infecciosas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Esp\u00edrito Santo , Vit\u00f3ria 29043-910 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila O V","family":"Oliveira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Doen\u00e7as Infecciosas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Esp\u00edrito Santo , Vit\u00f3ria 29043-910 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-0061","authenticated-orcid":false,"given":"Carlos","family":"Graeff-Teixeira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Doen\u00e7as Infecciosas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal 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