{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:39:46Z","timestamp":1774442386526,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The current study is a retrospective study designed to evaluate changes in complete blood count and coagulation parameters in adult coronavirus disease 2019 (COVID-19) patients at a prominent Saudi tertiary center to predict disease severity and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cohort consisted of 74 800 adult patients divided into four groups based on a COVID-19 test and the patient\u2019s sex: 35 985 in the female negative COVID-19 group, 23 278 in the male negative COVID-19 group, 8846 in the female positive COVID-19 group and 6691 in the male positive COVID-19 group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with COVID-19 demonstrated decreased white blood cell counts and increased red blood cell counts. Also, COVID-19\u2013positive participants exhibited more prolonged partial thromboplastin time and lower D-dimer levels than those of COVID-19\u2013negative subjects (p&amp;lt;0.05). The study also revealed gender-dependent impacts on platelet counts, implying a possible relationship with the greater infection mortality rate in men than in women (p&amp;lt;0.001). In addition, the study found a link between changes in coagulation test results and death in COVID-19 patients (p&amp;lt;0.001). The evidence regarding the effects of COVID-19 on blood cell counts and coagulation, on the other hand, is conflicting, most likely due to variances in study populations and the timing of testing postinfection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>According to the findings, COVID-19\u2013related alterations in blood cell count and clotting ability may be risk factors for death.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trae047","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:51:08Z","timestamp":1722477068000},"page":"773-780","source":"Crossref","is-referenced-by-count":1,"title":["Assessing the impact of severe acute respiratory syndrome\u00a0coronavirus\u00a02\u00a0infection on hematological parameters"],"prefix":"10.1093","volume":"118","author":[{"given":"Badi 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