{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:09:11Z","timestamp":1777093751213,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010409","name":"Children's Investment Fund Foundation","doi-asserted-by":"publisher","award":["R-1805-02741"],"award-info":[{"award-number":["R-1805-02741"]}],"id":[{"id":"10.13039\/100010409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Community-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trae059","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T18:27:57Z","timestamp":1724956077000},"page":"829-831","source":"Crossref","is-referenced-by-count":6,"title":["Patterns of soil-transmitted helminth aggregation in the human host population after several years of intensive mass drug administration"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0593-822X","authenticated-orcid":false,"given":"Julia","family":"Mayer","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building , 90 Wood Lane, London W12 0BZ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin S","family":"Collyer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building , 90 Wood Lane, London W12 0BZ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-3103","authenticated-orcid":false,"given":"Rosie","family":"Maddren","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building , 90 Wood Lane, London W12 0BZ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birhan","family":"Abtew","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building , 90 Wood Lane, London W12 0BZ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewnetu Firdawek","family":"Liyew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melkie","family":"Chernet","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getachew","family":"Tollera","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geremew","family":"Tasew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy M","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building , 90 Wood Lane, London W12 0BZ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"2024121305411387400_bib1","article-title":"Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030","author":"World Health Organization","year":"2020"},{"key":"2024121305411387400_bib2","first-page":"1","volume-title":"Advances in Parasitology","author":"Anderson","year":"1985"},{"key":"2024121305411387400_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0140-6736(16)32123-7","article-title":"Differential effect of mass deworming and targeted deworming 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