{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:01:22Z","timestamp":1746504082067,"version":"3.40.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sarawak General Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dengue is a vector-borne infection, which contributes to significant morbidity and mortality in endemic areas. It manifests rapidly within 2 wk from febrile, critical to recovery phase. The point-of-care test (POCT) comprises the non-structural protein 1 (NS1) antigen, IgM and IgG, which aids rapid diagnosis, leading to timely treatment. Despite the high specificity of various POCTs, a few false-positive NS1 cases have been reported. We report the first case of false-positive NS1 antigen in pregnancy. A 24-y-old female in her second trimester of pregnancy presented with fever and chills for 9 d and a non-productive cough for 3 d. The dengue POCT showed NS1 antigen positive, IgM and IgG negative. Her symptoms were resolved with treatment of urinary tract infection with cefuroxime. Urine culture subsequently yielded Escherichia coli. Her recovery and delivery were uneventful. Her NS1 antigen was persistently positive for 18 d. The confirmatory real time-PCR for dengue and pan-Flaviviruses was negative.<\/jats:p>","DOI":"10.1093\/trstmh\/trae134","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T08:43:34Z","timestamp":1734338614000},"page":"534-537","source":"Crossref","is-referenced-by-count":0,"title":["False-positive dengue non-structural protein 1 in pregnancy"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-4941","authenticated-orcid":false,"given":"Tonnii","family":"Sia","sequence":"first","affiliation":[{"name":"School of Public Health, Imperial College London , London SW7 2AZ ,","place":["UK"]},{"name":"Sarawak General Hospital Infectious Diseases Unit, Department of Medicine, , 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-cheng","family":"Wong","sequence":"additional","affiliation":[{"name":"Sarawak General Hospital Infectious Diseases Unit, Department of Medicine, , 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-chiing","family":"Ong","sequence":"additional","affiliation":[{"name":"Sarawak General Hospital Infectious Diseases Unit, Department of Medicine, , 93586 Kuching, Sarawak ,","place":["Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"Suppl 1","key":"2025050501565630000_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s13224-021-01562-2","article-title":"Fever during pregnancy: etiology and fetomaternal outcomes","volume":"72","author":"Brar","year":"2022","journal-title":"J Obstet Gynaecol India"},{"issue":"5","key":"2025050501565630000_bib2","doi-asserted-by":"crossref","first-page":"e2217","DOI":"10.1371\/journal.pntd.0002217","article-title":"Is pregnancy associated with severe dengue? A review of data from the Rio de Janeiro surveillance information system","volume":"7","author":"Machado","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"2025050501565630000_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3343\/alm.2019.39.6.566","article-title":"Comparison of six commercial diagnostic tests for the detection of Dengue Virus non-structural-1 antigen and IgM\/IgG antibodies","volume":"39","author":"Lee","year":"2019","journal-title":"Ann Lab Med"},{"key":"2025050501565630000_bib4","first-page":"w14296","article-title":"False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland","volume":"146","author":"Gyurech","year":"2016","journal-title":"Swiss Med Wkly"},{"issue":"12","key":"2025050501565630000_bib5","first-page":"e50146","article-title":"Dengue encephalitis versus Japanese encephalitis in cases of Dengue fever with altered sensorium: a diagnostic dilemma","volume":"15","author":"Yadav","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"2025050501565630000_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/v15020572","article-title":"The role of NS1 protein in the diagnosis of flavivirus infections","volume":"15","author":"Fisher","year":"2023","journal-title":"Viruses"},{"issue":"1","key":"2025050501565630000_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-3156.2007.01967.x","article-title":"A decade of Japanese encephalitis surveillance in Sarawak, Malaysia: 1997-2006","volume":"13","author":"Wong","year":"2008","journal-title":"Trop Med Int Health"},{"issue":"2","key":"2025050501565630000_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4269\/ajtmh.14-0247","article-title":"Two cases of false-positive dengue non-structural protein 1 (NS1) antigen in patients with hematological malignancies and a review of the literature on the use of NS1 for the detection of Dengue infection","volume":"92","author":"Chung","year":"2015","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"2025050501565630000_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s15010-016-0927-6","article-title":"Bacterial coinfections in dengue virus disease: what we know and what is still obscure about an emerging concern","volume":"45","author":"Trunfio","year":"2017","journal-title":"Infection"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/119\/5\/534\/61195578\/trae134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/article-pdf\/119\/5\/534\/61195578\/trae134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T05:57:24Z","timestamp":1746424644000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/119\/5\/534\/7925167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,12,16]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trae134","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"type":"print","value":"0035-9203"},{"type":"electronic","value":"1878-3503"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2024,12,16]]}}}