{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:36:07Z","timestamp":1790138167057,"version":"4.0.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["403215\/2022-6"],"award-info":[{"award-number":["403215\/2022-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["302722\/2022-0"],"award-info":[{"award-number":["302722\/2022-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["308986\/2022-9"],"award-info":[{"award-number":["308986\/2022-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies relating allelic variants in toll-like receptor (TLR) genes to the parasitological profile of Plasmodium vivax malaria are scarce. Therefore, we sought to assess whether polymorphisms in these genes can influence the clinical and parasitological aspects of individuals with P. vivax malaria in an endemic area from the Brazil\u2013French Guiana border.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 76 patients with P. vivax malaria. Parasitological parameters were collected, and genomic DNA was extracted from whole blood. The single nucleotide polymorphisms (SNPs) of TLR4 (rs4986790, rs4986791), TLR6 (rs5743810) and TLR9 genes (rs187084, rs5743836) were genotyped by qPCR. Association between the levels of parasitemia and gametocytes with the SNPs was performed using Kruskal\u2013Wallis and Mann\u2013Whitney tests. Parasitemia and gametocyte levels were adjusted for the polymorphisms using a linear regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a correlation between the TLR4 rs4986790, TLR6 rs5743810 and TLR9 rs187084 SNPs and parasitological aspects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results described here suggest that these genes\u2019 polymorphisms may have a role in the development of the inflammatory response during P. vivax malaria. The potential implications of these findings are discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/traf061","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T07:39:49Z","timestamp":1749541189000},"page":"1243-1249","source":"Crossref","is-referenced-by-count":2,"title":["Genetic markers at the crossroads:\n                    <i>toll-like receptor<\/i>\n                    polymorphisms and\n                    <i>Plasmodium vivax<\/i>\n                    malaria parasitological aspects from the Brazil\u2013French Guiana border"],"prefix":"10.1093","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-2728","authenticated-orcid":false,"given":"Marcelo","family":"Cerilo-Filho","sequence":"first","affiliation":[{"name":"Fluminense Federal University Postgraduate Program in Applied Microbiology and Parasitology, Microbiology and Parasitology Department, Biomedical Institute, , Niter\u00f3i 24020-141 Rio de 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Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata B","family":"Correa","sequence":"additional","affiliation":[{"name":"Fluminense Federal University Microorganisms Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrela C S","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Fluminense Federal University Postgraduate Program in Applied Microbiology and Parasitology, Microbiology and Parasitology Department, Biomedical Institute, , Niter\u00f3i 24020-141 Rio de Janeiro ,","place":["Brazil"]},{"name":"Fluminense Federal University Microorganisms Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marrara P","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Fluminense Federal University Postgraduate Program in Applied Microbiology and Parasitology, Microbiology and Parasitology Department, Biomedical Institute, , Niter\u00f3i 24020-141 Rio de Janeiro ,","place":["Brazil"]},{"name":"Fluminense Federal University Microorganisms Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo A","family":"Miceli","sequence":"additional","affiliation":[{"name":"Fluminense Federal University Microorganisms Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia F","family":"Reis","sequence":"additional","affiliation":[{"name":"Fluminense Federal University Postgraduate Program in Applied Microbiology and Parasitology, Microbiology and Parasitology Department, Biomedical Institute, , Niter\u00f3i 24020-141 Rio de Janeiro ,","place":["Brazil"]},{"name":"Fluminense Federal University Microorganisms Investigation Centre, Biomedical Institute, Department of Microbiology and Parasitology, , Niter\u00f3i 24020-141, Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens A O","family":"Menezes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Amap\u00e1 , Macap\u00e1 68903-419 Amap\u00e1 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete S 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