{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:11:41Z","timestamp":1762168301213,"version":"build-2065373602"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100013101","name":"National Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis A virus (HAV) and hepatitis E virus (HEV) continue to represent a significant global public health challenge. This study aims to assess the seroprevalence of anti-HAV immunoglobulin G (IgG) and anti-HEV IgG antibodies among blood donors in Paraguay, a region where epidemiological data on these infections are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples were collected from 452 blood donors in five regions of Paraguay and the presence of anti-HAV IgG and anti-HEV IgG antibodies was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 68.1% of donors tested positive for anti-HAV IgG, with a higher prevalence in older age groups (p&amp;lt;0.001) and significant regional differences (p&amp;lt;0.001). Notably, a low seroprevalence was found in the 18- to 25-y age group (36.4%), highlighting a potential gap in immunity. In contrast, anti-HEV IgG was detected in 6.0% of samples, with no significant differences observed across age groups or regions. Men exhibited a non-significant trend toward higher anti-HEV IgG seroprevalence compared with women (p=0.082).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high seroprevalence of anti-HAV IgG among older blood donors contrasts sharply with low coverage in younger adults, underscoring the critical need to prioritize and expand HAV vaccination efforts in younger adults. Furthermore, the low HEV seroprevalence suggests an opportunity for proactive surveillance and prevention, potentially addressing recent introduction or limited transmission. These results offer a valuable epidemiological foundation to guide effective disease control strategies and public health programs in Paraguay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/traf073","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:54:26Z","timestamp":1750319666000},"page":"1301-1306","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis A and hepatitis E virus seroprevalence in Paraguay: first survey among blood donors"],"prefix":"10.1093","volume":"119","author":[{"given":"Diego M","family":"Flichman","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y S\u00edndrome de Inmunodeficiencia Adquirida (INBIRS) , Paraguay 2155, Piso 11 CABA, Buenos Aires, PC: 1113 ,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Godoy Cruz 2290, Buenos Aires, PC: 1414 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Marquez","sequence":"additional","affiliation":[{"name":"Red Nacional de Servicios de Sangre del Ministerio de Salud P\u00fablica y Bienestar Social, avenida Silvio Pettirossi esquina Brasil , Asunci\u00f3n, PC: 001417 ,","place":["Paraguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro Productor de Sangre y Terapia Celular del Instituto de Previsi\u00f3n Social, Avenida Sant\u00edsimo Sacramento y Doctor Manuel Pe\u00f1a , Asunci\u00f3n, PC: 001417 ,","place":["Paraguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea S","family":"G\u00f3mez de la Fuente","sequence":"additional","affiliation":[{"name":"Centro Productor de Sangre y Terapia Celular del Instituto de Previsi\u00f3n Social, Avenida Sant\u00edsimo Sacramento y Doctor Manuel Pe\u00f1a , Asunci\u00f3n, PC: 001417 ,","place":["Paraguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Campus Universitario Ruta Mariscal Estigarribia Km. 11,5, Sn Lorenzo Universidad Nacional de Asunci\u00f3n, Departamento de Bioqu\u00edmica Cl\u00ednica de la Facultad de Ciencias Qu\u00edmicas, , PC: 001417 ,","place":["Paraguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Mercedes","family":"Elizalde","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y S\u00edndrome de Inmunodeficiencia Adquirida (INBIRS) , Paraguay 2155, Piso 11 CABA, Buenos Aires, PC: 1113 ,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Godoy Cruz 2290, Buenos Aires, PC: 1414 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