{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T07:54:41Z","timestamp":1772524481142,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Centre Medical d\u2019Oloumi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The immune response of people living with HIV (PLHIV) coinfected with intestinal and\/or blood helminths is still understudied in Gabon. The aim of this study was to compare IgE levels between HIV-positive and HIV-negative people depending on parasite carriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Samples from PLHIV and HIV-negative individuals, carriers or not of intestinal parasites and\/or microfilariae and\/or Plasmodium falciparum, were used as the study materials. The total IgE assay was performed using the VIDAS PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Samples from 152 participants were included in the study, 91 HIV-positive and 61 HIV-negative. Overall, 13.1% (n=20\/152) of the samples were infected with soil-transmitted helminths (STH), 29.0% (n=44\/152) with intestinal protozoa, 18.4% (n=28\/152) with P. falciparum and 36.8% (n=56\/152) by blood microfilariae. Median total IgE tended to be higher in HIV-negative participants compared with PLHIV (1287.0 kUI\/L; IQR 379.2\u20133975.2 kUI\/L vs 660.3 kUI\/L; IQR 236.9\u20133445.7 kUI\/L) (p=0.07). Carriers of STH had higher IgE levels than the other groups (p=0.02). There was a positive correlation between malaria parasitaemia, age and IgE levels in the HIV-negative group (rho=0.283; p=0.0008 and rho=0.5; p=0.0003, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed that PLHIV had lower IgE levels than HIV-negative people. Mansonella perstans and STH were associated with elevated IgE values, requiring further studies to better understand their immunomodulatory potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/traf125","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T08:58:11Z","timestamp":1766566691000},"page":"247-253","source":"Crossref","is-referenced-by-count":0,"title":["Total IgE levels in HIV-negative and HIV-positive individuals infected with parasites in rural settings of Gabon"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-3177","authenticated-orcid":false,"given":"B","family":"Pongui Ngondza","sequence":"first","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-3355","authenticated-orcid":false,"given":"N P","family":"M\u2019Bondoukw\u00e9","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-2334","authenticated-orcid":false,"given":"B C","family":"Moutoumbi Ditombi","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mayandza","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Mabicka Moussavou","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Manomba Boulingui","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-4365","authenticated-orcid":false,"given":"D P","family":"Mawili-Mboumba","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kombila","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. Box 4009 ,","place":["Gabon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-4630","authenticated-orcid":false,"given":"M K","family":"Bouyou-Akotet","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology and Tropical Medicine Service, Faculty of Medicine, Universit\u00e9 des Sciences de la Sant\u00e9 Department of Basic Sciences, , Owendo, P.O. 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