{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:50:46Z","timestamp":1786632646539,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223099\/Z\/21\/Z"],"award-info":[{"award-number":["223099\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral malaria is a major cause of death in endemic areas. An animal model of cerebral malaria has been studied widely in which C57BL\/6 mice are infected with the Plasmodium berghei ANKA strain. The histopathology and the response to interventions of human cerebral malaria and the murine model are very different. In 2012, a consensus guideline was published recommending that in order to represent better the clinical setting, interventions in the murine model should be tested together with antimalarial drug treatment and after development of the cerebral syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of publications on human and murine cerebral malaria since 2010 was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical research on human cerebral malaria has declined and still no adjuvant intervention has proved effective. Meanwhile, since 2010, 149 interventions (118 adjuvants) have been evaluated in the mouse model, of which 142 (95%) were reportedly successful. Only 26% of interventions were evaluated after the development of the murine cerebral syndrome and 65% of the adjuvants were tested without a concomitant antimalarial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The predictive value of the murine model in identifying adjuvant therapeutic interventions in human cerebral malaria is very poor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/traf126","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:06:07Z","timestamp":1763111167000},"page":"254-257","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral malaria: of mice and men"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-0943","authenticated-orcid":false,"given":"Chamarika J","family":"Weerasekera","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, University of Sri Jayewardenepura Department of Parasitology, , Gangodawila, Nugegoda ,","place":["Sri Lanka"]},{"name":"Faculty of Tropical Medicine, Mahidol University Mahidol\u2013Oxford Tropical Medicine Research Unit, , Bangkok 10400 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1978","authenticated-orcid":false,"given":"Nicholas J","family":"White","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University Mahidol\u2013Oxford Tropical Medicine Research Unit, , Bangkok 10400 ,","place":["Thailand"]},{"name":"University of Oxford Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, , Oxford OX3\u00a07LF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"issue":"Suppl 1","key":"2026030301563604200_bib1","first-page":"7","article-title":"Severe malaria","volume":"19","author":"World Health Organization","year":"2014","journal-title":"Trop Med Int Health"},{"issue":"2","key":"2026030301563604200_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1086\/589287","article-title":"The relationship between age and the manifestations of and mortality associated with severe malaria","volume":"47","author":"Dondorp","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"9487","key":"2026030301563604200_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"2026030301563604200_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm986","article-title":"Differentiating the pathologies of cerebral malaria by postmortem parasite counts","volume":"10","author":"Taylor","year":"2004","journal-title":"Nat Med"},{"issue":"654","key":"2026030301563604200_bib5","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1126\/scitranslmed.abn5040","article-title":"Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations","volume":"14","author":"Watson","year":"2002","journal-title":"Sci Transl Med"},{"key":"2026030301563604200_bib6","author":"World Health Organization","year":"2024","journal-title":"World malaria report 2024. 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