{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:28:42Z","timestamp":1777951722752,"version":"3.51.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["RED-00232-23"],"award-info":[{"award-number":["RED-00232-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chagas disease (CD) is a global health issue with acute and chronic forms that cause severe complications, especially affecting the heart. Inflammatory biomarkers have been proposed as potential predictors of adverse outcomes in CD, however, their clinical utility remains uncertain. We conducted a scoping review of five databases, including observational studies evaluating the diagnostic and\/or prognostic accuracy of inflammatory biomarkers in CD. Two reviewers independently screened and extracted data. Of 239 articles screened, 5 met the inclusion criteria. Adiponectin was associated with an increased risk of mortality and heart transplantation (hazard ratio 1.042 [95% confidence interval 1.013 to 1.072], area under the curve [AUC] 0.68, cut-off &amp;gt;38\u00a0\u03bcg\/ml). Tumour necrosis factor \u03b1 (TNF-\u03b1) and C-C motif chemokine ligand 2 (CCL2) were associated with left ventricular dysfunction (TNF-\u03b1: AUC 0.90; CCL2: AUC 0.69). Combined hepatocyte growth factor (HGF) and interleukin-12p40 (IL-12p40) predicted 3-y survival (accuracy 81.9%). Other biomarkers, including macrophage migration inhibitory factor, C-X-C motif chemokine ligand 12, monokine induced by interferon \u03b3 (MIG), transforming growth factor \u03b21 and matrix metalloproteinases 2 and 9, showed limited utility. While TNF-\u03b1 and HGF\/IL-12p40 showed promise, most inflammatory biomarkers demonstrated limited accuracy, specifically for outcome prediction in CD; however, this does not preclude their potential usefulness for other clinical or experimental applications. Current evidence does not support the clinical use of this approach and further studies are needed.<\/jats:p>","DOI":"10.1093\/trstmh\/traf150","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:22:05Z","timestamp":1767442925000},"page":"425-435","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of inflammatory biomarkers in assessing outcomes in Chagas disease: a scoping review"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-4521","authenticated-orcid":false,"given":"Matheus Ribeiro","family":"\u00c1vila","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 , Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Fr\u00f3is Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 , Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whesley Tanor","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical Research in Infectious Diseases, Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanny Cristina de Castro","family":"Faria","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal de Minas Gerais , Belo Horizonte 30130-100 , Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Felippe Felix","family":"Mediano","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical Research in Infectious Diseases, Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Ot\u00e1vio da Costa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 , Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Silveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri , Diamantina 39100-000 , Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Menezes-Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 , Minas Gerais ,","place":["Brazil"]},{"name":"Postgraduate Program in Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais , Belo Horizonte 31270-901 , Minas Gerais ,","place":["Brazil"]},{"name":"Universidade Federal de Minas Gerais Department of Clinical Pathology, COLTEC, , Belo Horizonte 31270-901 , Minas Gerais ,","place":["Brazil"]},{"name":"Vaccine Technology Center, Belo Horizonte Technology Park, Belo Horizonte 31310-260 , Minas 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