{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:46:52Z","timestamp":1783727212514,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021014","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["277\/2013"],"award-info":[{"award-number":["277\/2013"]}],"id":[{"id":"10.13039\/100021014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021014","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["27\/2017"],"award-info":[{"award-number":["27\/2017"]}],"id":[{"id":"10.13039\/100021014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021014","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["76\/2020"],"award-info":[{"award-number":["76\/2020"]}],"id":[{"id":"10.13039\/100021014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Brazilian Ministry of Health","doi-asserted-by":"publisher","award":["76\/2020"],"award-info":[{"award-number":["76\/2020"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["313451\/2021-4"],"award-info":[{"award-number":["313451\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lifelong protective immunity from a single dose of yellow fever (YF) vaccine remains controversial. We evaluated variations in YF neutralizing antibody titres over 4\u00a0years after primary vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort study was conducted in three municipalities in northeastern Brazil. The 17DD vaccine was administered between 2016 and 2018. Blood samples were collected to measure YF neutralizing antibodies before, 30\u201345\u00a0d, 1\u00a0y and 4\u00a0y after vaccination. Generalized linear mixed models with a Tweedie distribution were constructed for children and adults separately to estimate variation in antibody titres over the 4-y period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 4761 individuals, 2753 were children between 9\u00a0months and 4\u00a0y of age and 2008 adults ages 18\u201350\u00a0y. Four years after vaccination, seropositivity rates were 67.9% and 72.1% in children 9\u201323\u00a0months and 2\u20134\u00a0y, respectively, and 91.2% and 94.4% in adults 18\u201335 and 36\u201350\u00a0y, respectively. The ratio of means for neutralizing antibody titres 4\u00a0y after vaccination decreased to about one-third of that observed at 30\u201345\u00a0d after vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The evidence of waning immunity after a single dose of YF vaccine appears to support revaccination if primary vaccination targets infants and toddlers in endemic countries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag026","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:43:41Z","timestamp":1770986621000},"page":"641-651","source":"Crossref","is-referenced-by-count":1,"title":["A cohort study of the duration of immunity to yellow fever after 4\u00a0years of primary vaccination in children and adults"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9457-8768","authenticated-orcid":false,"given":"Camylla Veloso Valen\u00e7a","family":"Saucha","sequence":"first","affiliation":[{"name":"Escola Nacional de Sa\u00fade P\u00fablica Sergio Arouca (ENSP) Departamento de Epidemiologia, , Fiocruz, Rio de Janeiro-RJ, 21041-210 \u00a0","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel de Vasconcellos Carvalhaes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Epidemiologia Cl\u00ednica, Instituto Nacional de Infectologia Evandro Chagas (INI) , Fiocruz, Rio de Janeiro-RJ, 21041-360 \u00a0","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Lourdes de Sousa","family":"Maia","sequence":"additional","affiliation":[{"name":"Estudos Cl\u00ednicos e Vigil\u00e2ncia P\u00f3s-Registro (DEAME), Bio-Manguinhos: Instituto de Tecnologia em 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Reis","family":"Xavier","sequence":"additional","affiliation":[{"name":"Estudos Cl\u00ednicos e Vigil\u00e2ncia P\u00f3s-Registro (DEAME), Bio-Manguinhos: Instituto de Tecnologia em Imunobiol\u00f3gicos Departamento de Assuntos M\u00e9dicos, , Fiocruz, Rio de Janeiro-RJ, 21041-900 \u00a0","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita da Matta","family":"de Castro","sequence":"additional","affiliation":[{"name":"Estudos Cl\u00ednicos e Vigil\u00e2ncia P\u00f3s-Registro (DEAME), Bio-Manguinhos: Instituto de Tecnologia em Imunobiol\u00f3gicos Departamento de Assuntos M\u00e9dicos, , Fiocruz, Rio de Janeiro-RJ, 21041-900 \u00a0","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Leite de Souza","family":"Cruz","sequence":"additional","affiliation":[{"name":"Estudos Cl\u00ednicos e Vigil\u00e2ncia P\u00f3s-Registro (DEAME), Bio-Manguinhos: Instituto de Tecnologia em Imunobiol\u00f3gicos Departamento de 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