{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:02:44Z","timestamp":1780959764694,"version":"3.54.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Reference Centre for Hepatitis A"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis A virus (HAV), transmitted primarily through the faecal\u2013oral route, remains endemic in Mayotte, particularly among children. This study aims to assess the HAV epidemiology and circulating strains from 2017 to 2019 to evaluate prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between November 2017 and June 2019, 2434 patients were tested for HAV immunoglobulin M (IgM). Acute HAV infection was defined by HAV-IgM levels and clinical symptoms. Genotyping was performed using reverse transcription polymerase chain reaction and phylogenetic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 125 positive cases, 50 met the acute infection criteria, with a median age of 13\u00a0y. Most cases were mild and 28% required hospitalization. Phylogenetic analysis identified genotype IIIA, with a distinct \u2018Mahorese strain\u2019 circulating in Mayotte. A few cases were linked to travel to Madagascar and Pakistan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mayotte remains highly endemic for HAV, with a locally circulating strain. Improved sanitation and hygiene are crucial to control the spread of HAV, and while universal vaccination could help, hygiene measures should remain a priority.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag029","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:32:50Z","timestamp":1773145970000},"page":"668-672","source":"Crossref","is-referenced-by-count":0,"title":["In Mayotte French department, hepatitis A is still endemic"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-769X","authenticated-orcid":false,"given":"Lina","family":"Mouna","sequence":"first","affiliation":[{"name":"Paris Saclay University Hospital, APHP Virology Department, WHO Rubella National Reference Laboratory, Reference Laboratory for Perinatal Viral Infections, Department of Biology Genetics, Paul Brousse Hospital, , Villejuif ,","place":["France"]},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Paul Brousse, Service de Virologie, Universit\u00e9 Paris-Saclay , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Demortier","sequence":"additional","affiliation":[{"name":"Laboratoire du Centre Hospitalier de Mayotte , Mamoudzou ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Olivier","sequence":"additional","affiliation":[{"name":"Laboratoire du Centre Hospitalier de Mayotte , Mamoudzou ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Boutouaba","sequence":"additional","affiliation":[{"name":"Cellule Mayotte de Sant\u00e9 publique ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Subiros","sequence":"additional","affiliation":[{"name":"Cellule Mayotte de Sant\u00e9 publique ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Roque-Afonso","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Paul Brousse, Service de Virologie, Universit\u00e9 Paris-Saclay , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vauloup-Fellous","sequence":"additional","affiliation":[{"name":"Paris Saclay University Hospital, APHP Virology Department, WHO Rubella National Reference Laboratory, Reference Laboratory for Perinatal Viral Infections, Department of Biology Genetics, Paul Brousse Hospital, , Villejuif ,","place":["France"]},{"name":"INSERM U1184, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB\/IDMIT), Paris Saclay University , Fontenay-aux-Roses 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