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The blood stage, where parasites replicate inside red blood cells, causes disease symptoms and relies on large multiprotein surface complexes that are difficult to target. Understanding their structure is essential for rational vaccine design. Cryogenic electron microscopy (cryoEM) enables atomic-level analysis of dynamic and membrane-associated complexes without crystallization, revealing key processes such as protein trafficking, nutrient uptake, and host cell remodeling. Recent advances in artificial intelligence and deep learning have improved cryoEM data analysis and structural modeling. Together with genomic data, this integrated approach is accelerating progress toward broadly protective malaria vaccines.<\/jats:p>","DOI":"10.1093\/trstmh\/trag039","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:38:35Z","timestamp":1774957115000},"page":"802-804","source":"Crossref","is-referenced-by-count":0,"title":["Atomic clarity: how structural biology is shaping blood-stage malaria vaccines"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-8296","authenticated-orcid":false,"given":"Shrikant","family":"Nema","sequence":"first","affiliation":[{"name":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB) , Aruna Asaf Ali Marg, New Delhi, 110067 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Rathore","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Department of 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