{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:46:12Z","timestamp":1785905172445,"version":"3.56.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Molecular xenomonitoring (MX)\u2014the detection of filarial DNA in mosquito vectors\u2014has become an important component of post- mass drug administration surveillance within the Global Programme to Eliminate Lymphatic Filariasis (GPELF). MX offers non-invasive, high-sensitivity detection of residual or recrudescent Wuchereria bancrofti transmission, particularly where human microfilaraemia and antigenemia surveys have limited power. However, the current operational model relies heavily on gravid-trap\u2013based sampling, which captures a physiologically narrow, behaviourally biased subset of mosquitoes, often dominated by zoophagic Culex quinquefasciatus. This restricts interpretation and programme decision-making.<\/jats:p>\n                  <jats:p>We propose a restructured MX approach focused on representative multi-physiological sampling, routine blood-meal profiling, stage-specific molecular assays and harmonized analytical frameworks. With these refinements, MX can evolve into an actionable transmission\u2212intelligence platform vital for sustaining lymphatic filariasis elimination in the endgame phase.<\/jats:p>","DOI":"10.1093\/trstmh\/trag041","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:19:38Z","timestamp":1775474378000},"page":"895-897","source":"Crossref","is-referenced-by-count":0,"title":["Strengthening lymphatic filariasis elimination programmes with molecular xenomonitoring: critical utility and unmet operational needs"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-4614","authenticated-orcid":false,"given":"Sivagnaname","family":"Narayanasamy","sequence":"first","affiliation":[{"name":"Principal Technical Officer (Retired), ICMR\u2014Vector Control Research Centre , Puducherry 605006 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-6024","authenticated-orcid":false,"given":"Yuvarajan","family":"Sivagnaname","sequence":"additional","affiliation":[{"name":"Sri Manakula Vinayagar Medical College and Hospital Professor and Head, Department of Pulmonary Medicine, , Madagadipet, Puducherry 605107 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"2026080500012182000_bib1","first-page":"1068","article-title":"The global programme to eliminate lymphatic filariasis: health impact after 20 years","volume":"396","author":"Ottesen","year":"2020","journal-title":"Lancet"},{"key":"2026080500012182000_bib2","volume-title":"Global Programme to Eliminate Lymphatic Filariasis: Progress Report 2023","author":"World Health 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