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Drawing on lateral flow development and haemorrhagic fever case studies, we highlight the requirement for pre-established diagnostic building blocks, including monoclonal antibodies, antigens, biological reference materials and regulatory pathways. Persistent funding imbalances and inequitable global investment threaten timely outbreak response. Sustained preparedness investment, strengthened biobanking and equitable access frameworks will ensure that diagnostics can be delivered within meaningful response timelines.<\/jats:p>","DOI":"10.1093\/trstmh\/trag052","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:40:08Z","timestamp":1776253208000},"page":"898-900","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostics and the 100-day mission: why preparedness cannot wait"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1763-8863","authenticated-orcid":false,"given":"Caitlin R","family":"Thompson","sequence":"first","affiliation":[{"name":"Liverpool School of Tropical Medicine Clinical Sciences Department, , Liverpool L3 5QA ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-2835","authenticated-orcid":false,"given":"Emily 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