{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:51:56Z","timestamp":1791190316168,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac involvement is an underrecognized but potentially life-threatening complication of dengue fever. We aimed to estimate the prevalence and identify predictors of cardiac involvement among hospitalized patients with dengue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study including 919 patients with confirmed dengue. Cardiac involvement was defined based on clinical features (e.g. chest pain, dyspnoea, syncope), electrocardiogram (ECG) changes, elevated cardiac biomarkers (high-sensitivity troponin I [hs-troponin I] or N-terminal pro-hormone of brain natriuretic peptide) or echocardiographic abnormalities. We performed multivariable logistic regression to identify independent predictors and developed a classification and regression tree (CART) model for risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 14% of patients had cardiac involvement such as pericardial effusion (26%), elevated hs-troponin I (38%) and ECG abnormalities (10%). Significant associated factors were age &amp;gt;60\u00a0y (adjusted odds ratio [aOR] 3.05 [95% confidence interval {CI} 1.53 to 6.08]), warning signs (aOR 2.77 [95% CI 1.76 to 4.37]), anaemia (aOR 1.84 [95% CI 1.16 to 2.95]), thrombocytopenia (aOR 1.82 [95% CI 1.09 to 3.11]), elevated serum creatinine (aOR 2.20 [95% CI 1.34 to 3.60]), hypoalbuminaemia (aOR 3.06 [95% CI 1.74 to 5.57]) and elevated D-dimer levels (aOR 5.90 [95% CI 3.67 to 9.54]). The CART model identified age, warning signs, D-dimer and platelet count as significant predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac complications are common in dengue and should be considered in the management of high-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag059","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:04:57Z","timestamp":1777842297000},"page":"1012-1020","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and factors associated with cardiac involvement in hospitalized patients with dengue: a cross-sectional study"],"prefix":"10.1093","volume":"120","author":[{"given":"Sadeed Araf","family":"Reza","sequence":"first","affiliation":[{"name":"Sir Salimullah Medical College Mitford Hospital , Dhaka 1100 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