{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:15:21Z","timestamp":1788340521464,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dengue remains a major public health challenge in endemic regions, and conventional vector-control strategies have shown limited long-term effectiveness. The release of Wolbachia-infected Aedes aegypti mosquitoes has emerged as a novel biocontrol strategy to reduce dengue transmission. We conducted a systematic review and meta-analysis to evaluate the effectiveness of Wolbachia deployments in reducing dengue incidence. We searched PubMed, Embase, and the Cochrane Library until 30 April 2025 for randomized controlled trials and quasi-experimental studies conducted in dengue-endemic settings. Population-level effectiveness was assessed using pooled incidence rate ratios (IRRs), and individual-level protective efficacy using pooled odds ratios (ORs). Random-effects meta-analysis with restricted maximum likelihood with Hartung\u2013Knapp adjustment was applied. Subgroup analyses examined geographic region and deployment coverage. Nine studies involving &amp;gt;8 million individuals were included. Wolbachia deployment was associated with a substantial reduction in dengue incidence (pooled IRR 0.15, 95% CI 0.05\u20130.39), corresponding to an estimated 85% reduction. Full-area deployments demonstrated greater reductions (IRR 0.046, 95% CI 0.038\u20130.055) than partial-area deployments (IRR 0.22, 95% CI 0.07\u20130.74). Exploratory individual-level analyses yielded a pooled OR of 0.29 (95% CI 0.01\u20138.41) with substantial heterogeneity (I\u00b2 = 86.5%).<\/jats:p>","DOI":"10.1093\/trstmh\/trag063","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:50:59Z","timestamp":1778673059000},"page":"912-921","source":"Crossref","is-referenced-by-count":1,"title":["Impact of\n                    <i>Wolbachia<\/i>\n                    -infected\n                    <i>Aedes aegypti<\/i>\n                    on dengue incidence in endemic regions: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4624-6013","authenticated-orcid":false,"given":"Husni Mubarak","family":"Zainal","sequence":"first","affiliation":[{"name":"Borders General Hospital General Medicine Department, , Melrose, TD6 9BS ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9808-9163","authenticated-orcid":false,"given":"Ricardo Soares","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Departamento de Medicina e Ci\u00eancias M\u00e9dicas, Universidade Nove de Julho , S\u00e3o Paulo, S\u00e3o Paulo 01525 -000,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4209-6014","authenticated-orcid":false,"given":"Abdullah","family":"Al Owesie","sequence":"additional","affiliation":[{"name":"Jessenius Faculty of Medicine Department of Medicine, , Martin , 036 01,","place":["Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0281-9191","authenticated-orcid":false,"given":"Laura Santos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"University of Turin Department of Medicine Programme, , Turin 10124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-9244","authenticated-orcid":false,"given":"Andrea","family":"Roman-Pimentel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Applied Sciences , Lima 15023 ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5084-7707","authenticated-orcid":false,"given":"Tanika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Indira Gandhi Medical College Department of Medicine, , Shimla, Himachal Pradesh 171001 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-8728","authenticated-orcid":false,"given":"Vitoria Nallin","family":"de Godoy","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Taubat\u00e9, Universidade de Taubat\u00e9. Taubat\u00e9 , S\u00e3o Paulo 12030 -180","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-6497","authenticated-orcid":false,"given":"Rafael Bezerra","family":"Mendes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal do Maranh\u00e3o. S\u00e3o Lu\u00eds , Maranh\u00e3o 65080-805 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"2026090204265122900_bib1","article-title":"Dengue","volume-title":"CDC Yellow Book: Health Information for International Travel","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2025"},{"key":"2026090204265122900_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.34172\/hpp.2021.48","article-title":"Tackling the global health threat of arboviruses: an appraisal of the three holistic approaches to health","volume":"11","author":"Tajudeen","year":"2021","journal-title":"Health Promot Perspect"},{"key":"2026090204265122900_bib3","doi-asserted-by":"crossref","first-page":"e0012932","DOI":"10.1371\/journal.pntd.0012932","article-title":"Assessing the global dengue burden: incidence, mortality, and disability trends over three decades","volume":"19","author":"Zhang","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"2026090204265122900_bib4","volume-title":"Global dengue surveillance dashboard","author":"World Health Organization","year":"(6  2025"},{"key":"2026090204265122900_bib5","article-title":"Dengue","author":"World Health Organization","year":"2025","journal-title":"Fact sheet"},{"key":"2026090204265122900_bib6","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/S2214-109X(23)00590-9","article-title":"TAK-003 dengue vaccine as a new tool to mitigate dengue in countries with a high disease burden","volume":"12","author":"Wilder-Smith","year":"2024","journal-title":"Lancet Glob Health"},{"key":"2026090204265122900_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1574-6968.2008.01110.x","article-title":"How many species are infected with Wolbachia? 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